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Thiol-Norbornene Photoclick Chemistry for Grafting Antimicrobial Peptides onto ...

Alves, PM; Pereira, RF; Costa, B; Tassi, N; Teixeira, C; Leiro, V; Monteiro, C; Gomes, P; Costa, F; Martins, MCL

Covalent conjugation of antimicrobial peptides (AMP) is considered an effective approach to overcome their potential degradation in vivo. As the high cost of AMP-based therapies is one of the major hurdles towards their clinical application, it is urgently needed to explore high yield reactions. Herein, the highly efficient thiol-norbornene photoclick chemistry (TNPC) was explored for AMP grafting onto chitosan...

Date: 2022   |   Origin: Repositório Aberto da Universidade do Porto
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