6 documents found, page 1 of 1
Addressing neuroinflammation in human induced pluripotent stem cell-derived cen...
Gomes, Catarina M.; Simão, Daniel; Gonçalves, Carolina Cardoso; Silva, Gabriela; Painho, Beatriz; Alves, Paula Marques; Brito, CatarinaFunding Information: We gratefully acknowledge Dr Tomo \u0160aric ( University of Cologne , Germany) for the supply of hNPCs. This work was supported by Funda\u00E7\u00E3o para a Ci\u00EAncia e a Tecnologia (FCT) / Minist\u00E9rio da Educa\u00E7\u00E3o, Ci\u00EAncia e Inova\u00E7\u00E3o , through the Research Unit UID/04462: iNOVA4Health \u2013 Program in Translational Medicine, the Associate Laboratory LS4FUTU...
Aldehyde Dehydrogenase 2 (ALDH2)
Ferreira, Inês C.; Torrejón, Estefania; Abecasis, Bernardo; Alexandre, Bruno M.; Gomes, Ricardo A.; Verslype, Chris; van Pelt, Jos; Barbas, AnaFunding Information: We thank UniMS–Mass Spectrometry Unit from ITQB/iBET (Oeiras, Portugal) for MS data acquisition, and particular to Patrícia Alves, Ana Guerreiro and Catarina Correia for discussions and technical support on mass spectrometry. We thank Pedro Lamosa for discussions and technical support on NMR. We also thank Joerg Bomke, Pedro Sousa, Carolina Cassona, Inês Isidro and Inês Carrondo for fruitfu...
Miniaturization of hiPSC-derived 3D neural cultures in stirred-tank bioreactors...
Gomes, Catarina M.; Sebastião, Maria João; Silva, Gabriela; Moura, Filipa; Simão, Daniel; Gomes-Alves, Patrícia; Alves, Paula M.; Brito, CatarinaFunding Information: The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by FCT\u2014Funda\u00E7\u00E3o para a Ci\u00EAncia e a Tecnologia, I.P., through AstroReact (PTDC/BTM-ORG/29580/2017), iNOVA4Health (DOI 10.54499/UIDB/04462/2020; DOI 10.54499/UIDP/04462/2020) and LS4FUTURE Associated Laboratory (DOI 10.54499/LA/P/00...
Novel scFv against Notch Ligand JAG1 Suitable for Development of Cell Therapies...
Silva, Gabriela; Rodrigues, Ana F.; Ferreira, Susana; Matos, Carolina; Eleutério, Rute P.; Marques, Gonçalo; Kucheryava, Khrystyna; Lemos, Ana R.Funding Information: This research was funded by the Fundação para a Ciência e Tecnologia/Ministério da Ciência, Tecnologia e Ensino Superior (FCT/MCTES, Portugal) grant PTDC/BBB-BMD/4497/2014 (to A.B.), through national funds to iNOVA4Health (UIDB/04462/2020 and UIDP/04462/2020), and the Associate Laboratory LS4FUTURE (LA/P/0087/2020). Publisher Copyright: © 2023 by the authors.; The Notch signaling ligand JAG...
Lysosomal and network alterations in human mucopolysaccharidosis type VII iPSC-...
Bayó-Puxan, Neus; Terrasso, Ana Paula; Creyssels, Sophie; Simão, Daniel; Begon-Pescia, Christina; Lavigne, Marina; Salinas, Sara; Bernex, FlorenceMucopolysaccharidosis type VII (MPS VII) is a lysosomal storage disease caused by deficient β-glucuronidase (β-gluc) activity. Significantly reduced β-gluc activity leads to accumulation of glycosaminoglycans (GAGs) in many tissues, including the brain. Numerous combinations of mutations in GUSB (the gene that codes for β-gluc) cause a range of neurological features that make disease prognosis and treatment cha...
Recapitulation of Human Neural Microenvironment Signatures in iPSC-Derived NPC ...
Simão, Daniel; Silva, Marta M.; Terrasso, Ana P.; Arez, Francisca; Sousa, Marcos F.Q.; Mehrjardi, Narges Z.; Šarić, Tomo; Gomes-Alves, PatríciaBrain microenvironment plays an important role in neurodevelopment and pathology, where the extracellular matrix (ECM) and soluble factors modulate multiple cellular processes. Neural cell culture typically relies on heterologous matrices poorly resembling brain ECM. Here, we employed neurospheroids to address microenvironment remodeling during neural differentiation of human stem cells, without the confounding...