5 documents found, page 1 of 1
Role of MOB4 in cell proliferation and neurogenesis
Baião Santos, Inês; GARRIDO-MARAVER, JUAN; Gonçalves, Carolina; Oliveira, Bruna; Tavares, Alvaro A.Signaling pathways that integrate a large set of inputs (both extra- and intracellular) to control cell proliferation are essential during both development and adult stages to guarantee organism homeostasis. Mobs are small adaptor proteins that participate in several of these signaling pathways. Here, we review recent advances unravelling Mob4 cellular functions, a highly conserved non-catalytic protein, that p...
Spindly and Bub3 expression in oral cancer: Prognostic and therapeutic implicat...
Silva, Patricia M. A.; Delgado, Maria Leonor; Ribeiro, Nilza; Florindo, Claudia; Tavares, Alvaro A.; Ribeiro, Diana; Lopes, Carlos; do Amaral, BarbasObjectives Bub3 and Spindly are essential proteins required for the activation and inactivation of the spindle assembly checkpoint, respectively. Here, we explored the clinicopathological significance and the therapeutic potential of the opposing roles of the two proteins in oral squamous cell carcinoma (OSCC). Materials and Methods Bub3 and Spindly expression was evaluated by immunohistochemistry in 62 tissue ...
Co-silencing of human Bub3 and dynein highlights an antagonistic relationship i...
Silva, Patricia M. A.; Tavares, Alvaro A.; Bousbaa, HassanWe previously reported that the spindle assembly checkpoint protein Bub3 is involved in regulating kinetochore-microtubule (KT-MT) attachments. Also, Bub3 was reported to interact with the microtubule motor protein dynein. Here we examined how this interaction contributes to KT-MT attachments. Depletion of Bub3 or dynein induced misaligned chromosomes, consistent with their role in KT-MT attachments. Unexpected...
Mob1: defining cell polarity for proper cell division
Tavares, Alexandra; Gonçalves, João; Florindo, Claudia; Tavares, Alvaro A.; Soares, HelenaMob1 is a component of both the mitotic exit network and Hippo pathway, being required for cytokinesis, control of cell proliferation and apoptosis. Cell division accuracy is crucial in maintaining cell ploidy and genomic stability and relies on the correct establishment of the cell division axis, which is under the control of the cell's environment and its intrinsic polarity. The ciliate Tetrahymena thermophil...
Human Mob1 proteins are required for cytokinesis by controlling microtubule sta...
Florindo, Claudia; Perdigao, Joana; Fesquet, Didier; Schiebel, Elmar; Pines, Jonathon; Tavares, Alvaro A.The completion of cytokinesis requires abscission of the midbody, a microtubule-rich cytoplasmic bridge that connects the daughter cells before their final separation. Although it has been established that both the midbody structure and membrane fusion are essential for abscission, the biochemical machinery and the cellular processes of abscission remain ill-defined. Here we report that human Mob1A and Mob1B pr...