18 documents found, page 1 of 2
O ensaio do micronúcleo em células da mucosa bucal: aplicabilidade em biomonito...
Rosário, Rita Lopes; Tavares, Ana Maria; Louro, Henriqueta; Silva, Maria JoãoAs exposições ambientais e ocupacionais a alguns agentes químicos ou físicos representam sérios riscos para a saúde humana. A biomonitorização humana (BMH) permite quantificar a exposição a substâncias químicas e seus efeitos precoces através da caracterização de biomarcadores de exposição e de biomarcadores de efeito. O ensaio do micronúcleo em células bucais (MNBMCyt) é um biomarcador precoce de genotoxicidad...
Avaliação do risco da mistura de crómio hexavalente, níquel e hidrocarbonetos a...
Tavares, Ana Maria; Viegas, Susana; Louro, Henriqueta; Goen, Thomas; Santonen, Tiina; Luijten, Mirjam; Kortenkamp, Andreas; Silva, Maria JoãoNa maioria dos contextos laborais ocorre, em geral, exposição a misturas de substâncias químicas. Este estudo, inserido na iniciativa HBM4EU, visou avaliar o risco de exposição a misturas de crómio hexavalente [Cr ( VI ) ], níquel (Ni ) e/ou hicrocarbonetos aromáticos policíclicos (HAPs ) a partir de dados de exposição reportados em estudos realizados em várias indústrias na Europa. Para a avaliação do risco de...
Occupational Exposure to Hexavalent Chromium, Nickel and PAHs: A Mixtures Risk ...
Tavares, Ana Maria; Viegas, Susana; Louro, Henriqueta; Göen, Thomas; Santonen, Tiina; Luijten, Mirjam; Kortenkamp, Andreas; Silva, Maria JoãoHexavalent chromium (Cr(VI)), nickel (Ni) and polycyclic aromatic hydrocarbons (PAHs) are genotoxic co-occurring lung carcinogens whose occupational health risk is still understudied. This study, conducted within the European Human Biomonitoring Initiative (HBM4EU), aimed at performing a mixtures risk assessment (MRA) based on published human biomonitoring (HBM) data from Cr(VI), Ni and/or PAHs occupational co-...
Occupational exposure to metals and PAHs: combining literature-based exposure a...
Tavares, Ana Maria; Alves, Inês; Moreira, Rodrigo; Louro, Henriqueta; Ladeira, Carina; Viegas, Susana; Loureiro, Susana; Santonen, Tiina; Göen, ThomasThe environment within industrial settings is commonly characterized by the existence of a complex mixture of chemicals from different raw materials and transformation processes. Occupational co-exposure to chromium (Cr), Nickel (Ni), and Polycyclic Aromatic Hydrocarbons (PAHs) may occur in diverse workplaces, such as the aeronautic and waste management, (e.g incineration) sectors. Such co-exposure rais-es conc...
HBM4EU Occupational Biomonitoring Study on e-Waste-Study Protocol
Scheepers, Paul T.J.; Duca, Radu Corneliu; Galea, Karen S.; Godderis, Lode; Hardy, Emilie; Knudsen, Lisbeth E.; Leese, Elizabeth; Louro, HenriquetaWorkers involved in the processing of electronic waste (e-waste) are potentially exposed to toxic chemicals. If exposure occurs, this may result in uptake and potential adverse health effects. Thus, exposure surveillance is an important requirement for health risk management and prevention of occupational disease. Human biomonitoring by measurement of specific biomarkers in body fluids is considered as an effec...
O projeto HBM4EU - exemplo de biomonitorização da exposição ocupacional ao crómio
Tavares, Ana Maria; Louro, Henriqueta; Silva, Maria JoãoAula 5: O projeto HBM4EU - exemplo de biomonitorização da exposição ocupacional ao crómio. Projeto HBM4EU - General objective: To understand human exposure to chemicals and resulting health impacts and communicate with policy makers to ensure that the results are exploited in the design of new chemicals policies and the evaluation of existing measures.
Combined cytotoxic and genotoxic effects of ochratoxin A and fumonisin B1 in hu...
Pinhão, Mariana; Tavares, Ana Maria; Loureiro, Susana; Louro, Henriqueta; Alvito, Paula; Silva, Maria JoãoFood products can be contaminated by several fungi species and each species may produce different mycotoxins, leading to human combined exposure. Although predictions about the joint toxic effects of mycotoxins can be made from their individual toxicities, experimental data is still limited to allow a reliable hazard assessment. Thus, this study aimed to characterize the combined cytotoxic and genotoxic effects...
Risk assessment of combined occupational exposure to hexavalent chromium, nicke...
Tavares, Ana Maria; Viegas, Susana; Louro, Henriqueta; Silva, Maria JoãoOccupational exposure is usually characterized by a complex mixture of chemicals, originating from different raw materials and transformation processes. Co-exposure to hexavalent chromium (Cr(VI)), nickel (Ni) and polycyclic aromatic hydrocarbons (PAHs) can occur in some workplaces. These substances display well-known genotoxic and carcinogenic effects, especially in the respiratory tract, sharing similar modes...
Tuberculosis care for migrant patients in Portugal: a mixed methods study with ...
Tavares, Ana Maria; Garcia, Ana Cristina; Gama, Ana; Abecassis, Ana B.; Viveiros, Miguel; Dias, SóniaBackground: Tuberculosis (TB) is still a major global health problem. The increasing number of cases observed among foreign-born populations contrasts with the decreasing trends observed in later years in some high-income countries. Healthcare providers are key interveners in the control of TB and HIV-TB infections. In this study, we aimed to explore the perspectives of healthcare providers working in primary c...
The effects of matrix proteins on the aflatoxinM1 bioacessibility and the Caco-...
Tavares, Ana Maria; Egger, Charlotte; Portmann, Reto; Alvito, PaulaMycotoxins are fungal natural contaminants commonly found in food products that cause severe effects in human health, especially children. The mycotoxins occur in a great variety of foods, and can form complexes with the food matrix with a significant impact on their bioaccessibility. The bio-accessible fraction of the food contaminant contributes to the effective internal exposure depending on the contaminatio...