Agradecimentos: This study was supported by São Paulo Research Foundation (FAPESP) grant 2015/08330-5, grant 2014/00984-3 and the National Council for Scientific and Technological Development (CNPq) grant 409605/2016-6; Abstract: Environmentally induced changes in placental morphological and molecular phenotypes may provide relevant insight towards pathophysiology of diseases. Sickle cell disease (SCD) is a com...