2 documents found, page 1 of 1
Cu+/Ca2+ Dual‐overload strategy assisted by metabolic‐symbiotic‐destruction for...
Yan, Jiahui; Chen, Haoyu; Guimarães, Carlos Ferreira; Reis, R. L.; Zhu, Zhihua; Wang, Tianyi; Zhang, Fenglan; Zhou, Qihui; Kong, Xiaoying; Shi, JinshengIon interference including copper (Cu+)/calcium (Ca2+) overload activate cell-specific death channels, damage mitochondria and disrupt cellular homeostasis, showing great potential in anti-tumor therapy. However, the complex metabolic environment and the powerful self-protection of tumors cause clinical failure of ion interference. Thus, metabolic disruption is expected an innovative strategy for the enhancemen...
Activated immune system determines in vivo anti-tumor effect of phototherapy by...
Ding, Mengchao; Chen, Haoyu; Guimarães, Carlos Ferreira; Reis, R. L.; Wu, Lijuan; Zhang, Fenglan; Lv, Yaqian; Wang, Tianyi; Zhou, Qihui; Shi, JinshengImmune activation has been widely recognized to promote anti-tumor effects in vivo. However, in previous anti-tumor studies of combined photo/immunotherapy, the tumor apoptosis pathway is widely regarded as an independent process, which led to an incomplete understanding of the anti-tumor mechanisms of the immune system during phototherapy. Herein, the decisive role of immune activation for the anti-tumor effec...