41 documents found, page 1 of 5
Developing and evaluating a Portuguese-language meditation App for medical stud...
Soares, Ana Rita; Soares, Sandra; Brandão, Tânia; Teixeira, Ricardo João; Tavares, IsauraThe well-being of medical students is affected by high stress levels. The relevance of a mindfulness mediation app (Med@Med) specifically produced to help medical students at a Portuguese medical school cope with stress was evaluated. The app, consisting of 21 short meditations, was totally developed in Portuguese to fulfill with the needs of some of the students. The motivations to use the app, adherence to it...
Noradrenergic pathways involved in micturition in an animal model of hydrocepha...
Louçano, Marta; Coelho, Ana; Chambel, Sílvia Sousa; Prudêncio, Cristina; Cruz, Célia Duarte; Tavares, IsauraHydrocephalus is characterized by enlargement of the cerebral ventricles, accompanied by distortion of the periventricular tissue. Patients with hydrocephalus usually experience urinary impairments. Although the underlying etiology is not fully described, the effects of hydrocephalus in the neuronal network responsible for the control of urination, which involves periventricular areas, including the periaqueduc...
Neural control of the lower urinary tract during hydrocephalus
Louçano, Marta; Coelho, Ana; Chambel, Sílvia; Cruz, Célia Duarte; Tavares, IsauraNeurological impairments may affect the neural control of the Lower Urinary Tract (LUT), due to structural and functional changes. Hydrocephalic patients usually present a triad of symptoms, which include gait disturbances, dementia and urinary incontinence. The consequences of hydrocephalus in brain structures, namely those involved in neural control of micturition remain mostly unknown. We used a validated an...
Pain modulation from the Locus Coeruleus in a model of hydrocephalus: searching...
Louçano, Marta; Oliveira, Joana; Martins, Isabel; Vaz, Rui; Tavares, IsauraPain transmission at the spinal cord is modulated by noradrenaline (NA)-mediated actions that arise from supraspinal areas. We studied the locus coeruleus (LC) to evaluate the expression of the cathecolamine-synthetizing enzyme tyrosine hydroxylase (TH) and search for local oxidative stress and possible consequences in descending pain modulation in a model of hydrocephalus, a disease characterized by enlargemen...
Endothelium-mediated action of analogues of the endogenous neuropeptide kyotorp...
Perazzo, Juliana; Ferreira, Mónica Lopes; Santos, Sónia Sá; Serrano, Isa; Pinto, Antónia; Lima, Carla; Bardaji, Eduard; Tavares, IsauraKyotorphin (KTP) is an endogenous peptide with analgesic properties when administered into the central nervous system (CNS). Its amidated form (l-Tyr-l-Arg-NH2; KTP-NH2) has improved analgesic efficacy after systemic administration, suggesting blood-brain barrier (BBB) crossing. KTP-NH2 also has anti-inflammatory action impacting on microcirculation. In this work, selected derivatives of KTP-NH2 were synthesize...
Amidated and ibuprofen-conjugated kyotorphins promote neuronal rescue and memor...
Santos, Sónia Sá; Santos, Sara M.; Pinto, Antónia R. T.; Ramu, Vasanthakumar G.; Heras, Montserrat; Bardaji, Eduard; Tavares, IsauraChronic brain ischemia is a prominent risk factor for neurological dysfunction and progression for dementias, including Alzheimer's disease (AD). In rats, permanent bilateral common carotid artery occlusion (2VO) causes a progressive neurodegeneration in the hippocampus, learning deficits and memory loss as it occurs in AD. Kyotorphin (KTP) is an endogenous antinociceptive dipeptide whose role as neuromodulator...
Correlation between membrane translocation and analgesic efficacy in kyotorphin...
Serrano, Isa D.; Ramu, Vasanthakumar G.; Pinto, Antónia R. T.; Freire, João M.; Tavares, Isaura; Heras, Montserrat; Bardaji, Eduard R.Amidated kyotorphin (L-Tyr-L-Arg-NH2; KTP-NH2) causes analgesia when systemically administered. The lipophilic ibuprofen-conjugated derivative of KTP-NH2 has improved analgesic efficacy. However, fast degradation by peptidases impacts negatively in the pharmacodynamics of these drugs. In this work, selected derivatives of KTP and KTP-NH2 were synthesized to combine lipophilicity and resistance to enzymatic degr...
Neuropeptide kyotorphin (tyrosyl-arginine) has decreased levels in the cerebro-...
Santos, Sara Matos; Garcia-Nimo, Laura; Sá Santos, Sónia; Tavares, Isaura; Cocho, José A.; Castanho, Miguel A. R. B.In Alzheimer’s disease (AD), besides the characteristic deterioration of memory, studies also point to a higher pain tolerance in spite of sensibility preservation. A change in the normal tau protein phosphorylation is also characteristic of AD, which contributes to the pathogenesis of the disease and is useful in early diagnosis. Kyotorphin (KTP) is an endoge-nous analgesic dipeptide (Tyr-Arg) for which there ...
Side-effects of analgesic kyotorphin derivatives : advantages over clinical opi...
Ribeiro, Marta M. B.; Santos, Sónia Sá; Sousa, David S. C.; Oliveira, Margarida; Santos, Sara M.; Heras, Montserrat; Bardaji, Eduard; Tavares, IsauraThe adverse side-effects associated with opioid administration restrain their use as analgesic drugs and call for new solutions to treat pain. Two kyotorphin derivatives, kyotorphin-amide (KTP–NH2) and ibuprofen–KTP–NH2 (IbKTP–NH2) are promising alternatives to opioids: they trigger analgesia via an indirect opioid mechanism and are highly effective in several pain models following systemic delivery. In vivo si...
EGCG prevents the loss of pontine noradrenergic neurons induced by diabetes: a ...
Morgado, Carla; Silva, João; Miranda, André; Terra, Patrícia Daniela Pereira; Raposo, Diogo; Tavares, Isaura[Extract] Diabetes is a major health problem with an alarming increasing prevalence, and is the most frequent cause of neuropathy worldwide. Neuropathy affects 50-60% of diabetic patients, being a major life-quality impairment for a quarter of these patients