7 documents found, page 1 of 1
IL23R polymorphisms influence phenotype and response to therapy in patients wit...
Cravo, Marília; Ferreira, P. A.; Sousa, P.; Santos, Paula Moura dos; Velho, S.; Tavares, Lourdes; de Deus, J. R.; Ministro, P.; Peixe, P.Objective - We aimed to identify the clinical and genetic [IL23 receptor (IL23R) single nucleotide polymorphisms (SNPs)] predictors of response to therapy in patients with ulcerative colitis. Patients and methods - A total of 174 patients with ulcerative colitis, 99 women and 75 men, were included. The mean age of the patients was 47±15 years and the mean disease duration was 11±9 years. The number of patients ...
Intervenção do Fisioterapeuta na (dis)função respiratória em Pediatria - da com...
Tomé, David; Carvalho, Isabel; Ferraz, Catarina; Abreu, Paulo; Almeida, Sandrine; Ferreira, João José Pinto; Alexandrino, Ana Silva; Costa, DanielEste seminário pretendeu actualizar o estado da arte na abordagem da (dis)função respiratória da criança, uma vez que, nesta área, o fisioterapeuta amplificou os limites de actuação, para além do modelo biomédico. Num dos extremos encontra-se a intervenção comunitária, cujo modelo propicia a educação e promoção de saúde, privilegiando estratégias que capacitem o cuidador; no outro extremo inclui-se a intervençã...
Fat intake interacts with polymorphisms of Caspase9, FasLigand and PPARgamma ap...
Ferreira, Paula; Cravo, Marília; Guerreiro, Catarina Sousa; Tavares, Lourdes; Santos, Paula Moura dos; Brito, MiguelBackground & aims: Crohn’s disease (CD) is a multifactorial disease where resistance to apoptosis is one major defect. Also, dietary fat intake has been shown to modulate disease activity. We aimed to explore the interaction between four single nucleotide polymorphisms (SNPs) in apoptotic genes and dietary fat intake in modulating disease activity in CD patients. Methods: Polymerase Chain Reaction (PCR) and Res...
Risk factors for metabolic bone disease in Crohn's disease patients
Cravo, Marília; Guerreiro, Catarina Sousa; Santos, Paula Moura dos; Brito, Miguel; Ferreira, Paula; Fidalgo, Catarina; Tavares, LourdesBackground: The aim was to evaluate the presence of metabolic bone disease (MBD) in patients with Crohn’s disease (CD) and to identify potential etiologic factors. Methods: The case–control study included 99 patients with CD and 56 controls with a similar age and gender distribution. Both groups had dual-energy x-ray absorptionmetry and a nutritional evaluation. Single nucleotide polymorphisms at the IL1, TNF-a...
Fat intake interacts with polymorphisms of Caspase9, FasLigand and PPARgamma ap...
Ferreira, Paula; Cravo, Marília; Guerreiro, Catarina Sousa; Tavares, Lourdes; Santos, Paula Moura; Brito, MiguelBackground & aims: Crohn’s disease (CD) is a multifactorial disease where resistance to apoptosis is one major defect. Also, dietary fat intake has been shown to modulate disease activity. We aimed to explore the interaction between four single nucleotide polymorphisms (SNPs) in apoptotic genes and dietary fat intake in modulating disease activity in CD patients. Methods: Polymerase Chain Reaction (PCR) and Res...
Fatty acids, IL6, and TNFα polymorphisms: an example of nutrigenetics in Crohn'...
Guerreiro, Catarina Sousa; Ferreira, Paula; Tavares, Lourdes; Santos, Paula Moura dos; Neves, Manuela; Brito, Miguel; Cravo, MaríliaObjectives - The aim of this work was to study the interaction between genetic polymorphisms (single-nucleotide polymorphisms, SNPs) of pro- and anti-inflammatory cytokines and fat intake on the risk of developing Crohn's disease (CD) or modifying disease activity. Methods - Seven SNPs in interleukin 1 (IL1), tumor necrosis factor alpha (TNFalpha), lymphotoxin alpha (LTalpha), and IL6 genes were analyzed in 116...
A comprehensive approach to evaluate nutritional status in Crohn's patients in ...
Guerreiro, Catarina Sousa; Cravo, Marília; Costa, Ana Raimundo; Miranda, Ana; Tavares, Lourdes; Santos, Paula Moura dos; Vidal, Pedro MarquesObjectives - Evaluate the nutritional status of patients with inactive or mildly active Crohn's disease (CD), and identify possible causes for potential deficiencies. Methods - A total of 78 CD patients and 80 healthy controls were evaluated in respect of nutritional status, dietary intake, and life styles factors. Results - These 73/78 CD patients were on immunomodulating therapies. Mean body mass index (BMI) ...