2 documents found, page 1 of 1
Development of cross-resistance by Aspergillus fumigatus to clinical azoles fol...
Faria-Ramos, Isabel; Farinha, Sofia; Neves-Maia, João; Tavares, Pedro Ribeiro; Miranda, Isabel M.; Estevinho, Leticia M.; Pina-Vaz, CidáliaBackground: The purpose of this study was to unveil whether azole antifungals used in agriculture, similar to the clinical azoles used in humans, can evoke resistance among relevant human pathogens like Aspergillus fumigatus, an ubiquitous agent in nature. Additionally, cross-resistance with clinical azoles was investigated. Antifungal susceptibility testing of environmental and clinical isolates of A. fumigatu...
Environmental azole fungicide, prochloraz, can induce cross-resistance to medic...
Faria-Ramos, Isabel; Tavares, Pedro Ribeiro; Farinha, Sofia; Neves-Maia, João; Miranda, Isabel M.; Silva, Raquel M.; Estevinho, Leticia M.Acquisition of azole resistance by clinically relevant yeasts in nature may result in a significant, yet undetermined, impact in human health. The main goal of this study was to assess the development of cross-resistance between agricultural and clinical azoles by Candida spp. An in vitro induction assay was performed, for a period of 90 days, with prochloraz (PCZ) - an agricultural antifungal. Afterward, the i...