5 documents found, page 1 of 1
Layer-by-layer electrospun PCL/PVA mats loaded with nisin Z for enhanced diabet...
Tavares, Tânia; Pinho, Sonia L. C.; Delgado-Pujol, Ernesto J.; Begines, Belén; Alcudia, Ana; Silva, C.; Antunes, Joana C.; Felgueiras, Helena PradoDiabetic foot ulcers (DFUs) represent a significant clinical challenge due to impaired healing and high susceptibility to infections, underscoring the urgent need for multifunctional wound dressings. This study explores the potential of multilayered electrospun mats composed of polycaprolactone (PCL) and poly(vinyl alcohol) (PVA) engineered by a layer-by-layer (LbL) electrospun-based deposition, and functionali...
β-Lactoglobulin microparticles obtained by high intensity ultrasound as a poten...
Tavares, Tânia; Ramos, Óscar L.; Malcata, F. XavierThis work attempted to assess the effect of high intensity ultrasound (HIUS) upon development of bio-based delivery systems, from β-lactoglobulin (β-Lg) gelled microparticles, for encapsulation of a bioactive peptide concentrate (PepC). Solutions of 150 g L−1 of commercial β-Lg and 30 g L−1 PepC, at various pH values (3.0, 4.0 and 5.5), were accordingly subjected to gelation for 30 min using a dry bath kept at ...
Novel whey-derived peptides with inhibitory effect against angiotensin-converti...
Tavares, Tânia; Del Mar Contreras, Maria; Amorim, Manuela; Pintado, Manuela; Recio, Esidra; Malcata, F. XavierWhey protein concentrate (WPC) was subjected to enzymatic hydrolysis by proteases from the flowers of Cynara cardunculus, and the resulting angiotensin-converting enzyme (ACE)-inhibitory effect was monitored. The whole WPC hydrolysate exhibited an IC50 value of 52.9±2.9ºg/mL, whereas the associated peptide fraction with molecular weight below 3 kDa scored 23.6±1.1ºg/mL. The latter fraction was submitted to RP-H...
Development and analytical characterization of ofloxacin ion-selective electrodes
Souto, Renata; Pimenta, Adriana; Leal, Fernanda; Catarino, Rita; Santos, Gory; Tavares, TâniaAn ofloxacin-selective electrode based on incorporation of a ofloxacin-tetrakis[3,5- bis(trifluoromethyl)phenyl]borate ion-pair complex in a poly(vinyl chloride) membrane was developed. The sensor displayed a Nernstian response over a wide concentration range (7×10-6–1×10-2 mol L-1) with a slope of 54.9 ± 1.3 mV per decade of concentration, a detection limit of 4×10-6 mol L-1 and adequate selectivity toward som...
Angiotensin-converting enzyme-inhibitory activity of extracts of hydrolysed k-c...
Tavares, Tânia; Amorim, Manuela; Pintado, Manuela; Récio, Isidra; Malcata, F. XavierDietary proteins usually possess a wide range of nutritional, functional and biological properties; many of such biological properties have been attributed to physiologically active peptides, which are encrypted within the protein sequence. k‐Casein glycomacropeptide (CMP) – one of the main components of whey, is released in the first step of (enzymatic) cheese making – and has been claimed to act as mediator i...