14 documents found, page 1 of 2
Virtual Screening of Secondary Metabolites of the Family Velloziaceae J. Agardh...
Pinheiro,Anderson A. V.; Barros,Renata P. C.; Assis,Edileuza B. de; Maia,Mayara S.; Araújo,Diego I. A. F. de; Sales,Kaio A.; Scotti,LucianaThe objective of this work was to carry out a bibliographic survey of secondary metabolites isolated from the Velloziaceae family, creating a bank of compounds. After the bank was created, four prediction models for potentially active compounds against pathogenic microorganisms (Candida albicans, Escherichia coli, Pseudomonas aeruginosa and Salmonella sp.) were obtained trying to identify which metabolites woul...
DOIS NOVOS ALCALOIDES AZAFENANTRENO DE Anaxagorea dolichocarpa Sprague & Sa...
Sales,Kaio A.; Pinheiro,Anderson A. V.; Araújo,Diego I. A. F.; Andrade,Rodrigo S. de; Agra,Maria de Fátima; Sobral,Marianna V.; Magalhães,Hemerson I. F.A chemical investigation of Anaxagorea dolichocarpa Sprague & Sandwith, a member of Annonaceae family, was carried out. The ethanolic extract from the roots of this plant led, by chromatography tecniches, to isolation of the new azaphenanthrene alkaloids dolichocarpine (1) and 9-methoxyeupolauramine (2), besides the known alkaloids eupolauramine (3), 3-methoxyeupolauridine (4), eupolauramine (5) and 4-methylsam...
Zornioside, a dihydrochalcone C-glycoside, and other compounds from Zornia bras...
Nascimento,Yuri M.; Abreu,Lucas S.; Lima,Ramon L.; Silva,Anne Dayse S.; Costa,Vicente Carlos O.; Melo,José Iranildo M.; Scotti,Marcus TuliusABSTRACT The secondary metabolites of the aerial parts of Zornia brasiliensis Vogel, Fabaceae, and the biological activity of one of these secondary metabolites were characterized in this study. A phytochemical investigation was performed using chromatographic techniques including analytical and preparative reverse-phase HPLC column sequences, which resulted in the isolation of fourteen compounds: one previousl...
LUCLARICIN, A NEW LIGNAN FROM PHYLLANTHUS ACUMINATUS
Duarte,Susyanne L. F.; Nascimento,Yuri M.; Madeiro,Sara A. L.; Costa,Vicente C. O.; Agra,Maria F.; Sobral,Marianna V.; Braz-Filho,RaimundoThe secondary metabolites of the aerial parts of Phyllanthus acuminatus Vahl (Phyllanthaceae) and the biological activity of one of them were characterized in this study. This chemical investigation led to isolation of two lignans, luclaricin (1), a new arylnaphtalene-typelignan, and justicidin B (2). The structures of isolated compounds were determined based on 1D and 2D-NMR, HRESIMS and IR. The cytotoxic acti...
Toxicity and antitumor efficacy of Croton polyandrus oil against Ehrlich ascite...
Meireles,Déborah R.P.; Fernandes,Heloísa M.B.; Rolim,Thaísa L.; Batista,Tatianne M.; Mangueira,Vivianne M.; Sousa,Tatyanna K.G. de; Pita,João C.L.R.ABSTRACT The essential oil from Croton polyandrus Spreng., Euphorbiaceae, leaves was tested for the toxicity and antitumor activity. The concentration producing 50% hemolysis was 141 µg/ml on mice erythrocytes. In the acute toxicological study, the estimated LD50 was 447.18 mg/kg. The essential oil did not induce increase in number of micronucleated erythrocytes, suggesting low genotoxicity. Essential oil (100 ...
Phytochemical study and antinociceptive effect of the hexanic extract of leaves...
Quintans,Jullyana S.S.; Costa,Emmanoel V.; Tavares,Josean F.; Souza,Thais T.; Araújo,Silvan S.; Estevam,Charles S.; Barison,AnderssonCombretum duarteanum Cambess, Combretaceae, is a plant widely distributed in Northeastern Brazil and, in folk medicine, stems and leaves are used for pain treatment. We investigated the antinociceptive effects of the hexanic extract of leaves from C. duarteanum and of friedelin, its main compound, in formalin-, glutamate- and capsaicin- induced orofacial nociception models. In order to isolate friedelin from th...
New neolignans from Krameria tomentosa A. St. -Hil
Madeiro,Sara A. L.; Lucena,Hellane F. S. de; Siqueira,Caroline D.; Duarte,Marcelo C.; Braz-Filho,Raimundo; Barbosa Filho,José M.; Silva,Marcelo S. daA phytochemical investigation of the roots of Krameria tomentosa A. St. -Hil. led to the isolation of five neolignans, two of them with novel structures [1,1'-(E)-propenyl-4-methoxy3,4'-oxyneolignan (ottomentosa) and 2-(2'-hydroxy-4',6'-dimethoxyphenyl)benzofuran5-carboxylic acid (sobraline)] and three known compounds [eupomatenoid 6, dihydrocarinatidin and 2-(2',4'-dihydroxyphenyl)-5-(E)-propenylbenzofuran]. T...
Constituintes químicos das folhas de Rollinia leptopetala R. E. Fries
Costa,Vicente Carlos de O.; Tavares,Josean F.; Queiroga,Cinthia S.; Castello-Branco,Marianna V. S.; Diniz,Margareth F. F. MeloThe phytochemical investigation of Rollinia leptopetala led to the isolation of a new compound named α-terpinyl caffeate, and five known compounds, being three sesquiterpenes, spathulenol, β-caryophyllene and 4β,10α-aromadendrane-diol, and two alkaloids, (-)-3-hydroxynornuciferine and (+)-norisocorydine. These alkaloids are being described for the first time in this genus. The structures of the compounds were d...
Xylodiol from Xylopia langsdorfiana induces apoptosis in HL60 cells
Castello-Branco,Marianna Vieira S.; Tavares,Josean F.; Silva,Marcelo S.; Barbosa Filho,José Maria; Anazetti,Maristella C.; Frungillo,Lucas; Haun,MarcelaAn atisane diterpene was isolated from Xylopia langsdorfiana St. Hilaire & Tulasne, Annonaceae, leaves, ent-atisane-7α,16α-diol (xylodiol). Preliminary study showed that xylodiol was cytotoxic and induced differentiation on human leukemia cell lines. However, the molecular mechanisms of xylodiol-mediated cytotoxicity have not been fully defined. Thus, we investigated the anti-tumor effect of xylodiol in hum...
Effects of extract, fractions and 2,3-dihydromyricetin-3-O-α-L-rhamnoside from ...
Medeiros,Alessandra A. N.; Medeiros,Fernando A.; Queiroz,Thyago M.; Tavares,Josean F.; Silva,Marcelo S.; Medeiros,Isac A.Pradosia huberi (Ducke) Ducke (Sapotaceae), an Amazonian species, is popularly known as "casca-doce" and used in the folk medicine for the treatment of gastritis. The ethanol extract of the bark contains mainly polyphenolic compounds, which are known to show a large number of activities, including cardioprotective and vasorelaxant effects. The aim of this study was to evaluate the pharmacological properties ind...