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The percentage of −2 pro–prostate-specific antigen and the prostate health inde...
Garrido, Manuel Matos; Marta, José C.; Bernardino, Rui M.; Guerra, João; Fernandes, Francisco; Pereira, Maria H.; Ribeiro, Ruy; Holdenrieder, StefanContext.—: There is a need to avoid the overdiagnosis of prostate cancer (PCa) and to find more specific biomarkers. Objective.—: To evaluate the clinical utility of [-2]pro-prostate-specific antigen ([-2]proPSA) derivatives in detecting clinically significant PCa (csPCa) and to compare it with prostate-specific antigen (PSA) and with the percentage of free PSA (%fPSA). Design.—: Two hundred thirty-seven men (P...
Are proinflammatory cytokines relevant for the diagnosis of prostate cancer?
Garrido, Manuel Matos; Ribeiro, Ruy; Krüger, Kimberly; Pinheiro, Luís C.; Guimarães, João T.; Holdenrieder, StefanBackground/aim: Inflammation plays an important role in prostate cancer (PCa). We evaluated proinflammatory cytokines regarding differential diagnosis of PCa in men with PSA levels between 2-10 ng/ml. Patients and methods: Serum samples of 79 men (PSA 2-10 ng/ml) were analyzed for 10 proinflammatory cytokines (IL-6, IL-8, TNF-α, IFN-γ, IL-10, IL-1β, IL-2, IL-4, IL-12p70, IL-13) and results were evaluated regard...
The prostate health index (PHI) density : are there advantages over PHI or over...
Garrido, Manuel Matos; Ribeiro, Ruy; Pinheiro, Luís C.; Holdenrieder, Stefan; Guimarães, João T.Background and aims: Overdiagnosis of prostate cancer (PCa) should be minimized. We wanted to evaluate the diagnostic performance of the prostate health index density (PHID) and compare it with that of the prostate health index (PHI) alone and of the prostate-specific antigen density (PSAD). Materials and methods: 232 men scheduled for a prostate biopsy (prostate-specific antigen level: 2-10 µg/L), were enrolle...
Central and peripheral body fat distribution: Different associations with low-g...
Cabral, Maria Bangdiwala; Bangdiwala, Shrikant I.; Severo, Milton; Guimarães, João T.; Nogueira, Luisa; Ramos, ElisabeteBackground and aimsEvidence regarding the impact of regional body fat distribution on low-grade inflammation is limited. The current study examined the association of central and peripheral body fat distribution and low-grade inflammation levels in young adults, considering collinearity between variables.
Adipose tissue dysfunction as a central mechanism leading to dysmetabolic obesi...
Pestana, Diogo; Teixeira, Diana; Meireles, Manuela; Marques, Cláudia; Norberto, Sónia; Sá, Carla; Fernandes, Virgínia; Correia-Sá, Luísa; Faria, AnaEndocrine-disrupting chemicals such as p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE), are bioaccumulated in the adipose tissue (AT) and have been implicated in the obesity and diabetes epidemic. Thus, it is hypothesized that p,p'-DDE exposure could aggravate the harm of an obesogenic context. We explored the effects of 12 weeks exposure in male Wistar rats' metabolism and AT biology, assessing a range of met...
Excess perigestational folic acid exposure induces metabolic dysfunction in pos...
Keating, Elisa; Correia-Branco, Ana; Araújo, João R,; Meireles, Manuela; Fernandes, Rita; Guardão, Luísa; Guimarães, João T.; Martel, FátimaThe aim of this study was to understand whether high folic acid (HFA) exposure during the perigestational period induces metabolic dysfunction in the offspring, later in life. To do this, female Sprague-Dawley rats (G0) were administered a dose of folic acid (FA) recommended for pregnancy (control, C, 2 mg FA/kg of diet, n=5) or a high dose of FA (HFA, 40 mg FA/kg of diet, n=5). Supplementation began at mating ...
The chemopreventive effect of the dietary compound kaempferol on the MCF-7 huma...
Azevedo, Cláudia; Correia-Branco, Ana; Araújo, João R.; Guimarães, João T.; Keating, Elisa; Martel, FátimaOur aim was to investigate the effect of several dietary polyphenols on glucose uptake by breast cancer cells. Uptake of H-3-deoxy-D-glucose (H-3-DG) by MCF-7 cells was time-dependent, saturable, and inhibited by cytochalasin B plus phloridzin. In the short-term (26min), myricetin, chrysin, genistein, resveratrol, kaempferol, and xanthohumol (10-100 mu M) inhibited H-3-DG uptake. Kaempferol was found to be the ...
Persistent organic pollutant levels in human visceral and subcutaneous adipose ...
Pestana, Diogo; Faria, Gil; Sá, Carla; Fernandes, Virgínia C.; Teixeira, Diana; Norberto, Sónia; Faria, Ana; Meireles, Manuela; Marques, CláudiaBackground: The role of persistent organic pollutants (POPs) with endocrine disrupting activity in the aetiology of obesity and other metabolic dysfunctions has been recently highlighted. Adipose tissue (AT) is a common site of POPs accumulation where they can induce adverse effects on human health. Objectives: To evaluate the presence of POPs in human visceral (vAT) and subcutaneous (scAT) adipose tissue in a ...
Response of bone mineral density, inflammatory cytokines, and biochemical bone ...
Marques, Elisa A.; Mota, Jorge; Viana, João L.; Tuna, Diana; Figueiredo, Pedro; Guimarães, João T.; Carvalho, JoanaThis study examines the effects of 32 weeks of exercise training on balance, lower-extremity muscle strength, bone mineral density (BMD) and serum levels of bone metabolism and inflammatory markers in older adults. Forty-seven healthy older adults (women=24, men=23; mean age 68.2 years) participated in a exercise intervention (60min/session) that included resistance exercise training (2 days/week) at 75-80% of ...
Xanthohumol-supplemented beer modulates angiogenesis and inflammation in a skin...
Negrão, Rita; Costa, Raquel; Duarte, Delfim; Gomes, Tiago Taveira; Coelho, Pedro; Guimarães, João T.; Guardão, Luísa; Azevedo, Isabel; Soares, RaquelAngiogenesis and inflammation are two intermingled processes that play a role in wound healing. Nevertheless, whenever exacerbated, these processes result in nonhealing wounds. Xanthohumol (XN), a beer-derived polyphenol, inhibits these processes in many physiopathological situations. This study aimed at examining whether XN ingestion affects wound healing. Wistar rats drinking water, 5% ethanol, stout beer (SB...