24 documents found, page 1 of 3
Global age-sex-specific mortality, life expectancy, and population estimates in...
Schumacher, AE; Kyu, HH; Aali, A; Abbafati, C; Abbas, J; Abbasgholizadeh, R; Abbasi, MA; Abbasian, M; Abd ElHafeez, S; Abdelmasseh, M; Abd Elsalam, SBackground: Estimates of demographic metrics are crucial to assess levels and trends of population health outcomes. The profound impact of the COVID-19 pandemic on populations worldwide has underscored the need for timely estimates to understand this unprecedented event within the context of long-term population health trends. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 provides n...
Mapping age- and sex-specific HIV prevalence in adults in sub-Saharan Africa, 2...
Haeuser, E; Serfes, AL; Cork, MA; Yang, M; Abbastabar, H; Abhilash, ES; Adabi, M; Adebayo, OM; Adekanmbi, V; Adeyinka, DA; Afzal, S; Ahinkorah, BOBackground: Human immunodeficiency virus and acquired immune deficiency syndrome (HIV/AIDS) is still among the leading causes of disease burden and mortality in sub-Saharan Africa (SSA), and the world is not on track to meet targets set for ending the epidemic by the Joint United Nations Programme on HIV/AIDS (UNAIDS) and the United Nations Sustainable Development Goals (SDGs). Precise HIV burden information is...
Subnational mapping of HIV incidence and mortality among individuals aged 15–49...
Sartorius, B; VanderHeide, JD; Yang, M; Goosmann, EA; Hon, J; Haeuser, E; Cork, MA; Perkins, S; Jahagirdar, D; Schaeffer, LE; Serfes, AL; LeGrand, KEBackground. High-resolution estimates of HIV burden across space and time provide an important tool for tracking and monitoring the progress of prevention and control efforts and assist with improving the precision and efficiency of targeting efforts. We aimed to assess HIV incidence and HIV mortality for all second-level administrative units across sub-Saharan Africa. Methods. In this modelling study, we devel...
Mapping routine measles vaccination in low- and middle-income countries
Sbarra, AN; Rolfe, S; Nguyen, JQ; Earl, L; Galles, NC; Marks, A; Abbas, KM; Abbasi-Kangevari, M; Abbastabar, H; Abd-Allah, F; Abdelalim, A; Abdollahi, M
In Vitro Evaluation of Novel Reverse Transcriptase Inhibitors TAF (Tenofovir Al...
Bártolo, I; Borrego, P; Gomes, P; Gonçalves, F; Caixas, U; Pinto, IV; Taveira, NNew antiretroviral drugs are needed to treat HIV-2 infected patients failing therapy. Herein, we evaluate the activity of novel reverse transcriptase inhibitors tenofovir alafenamide (TAF) and OBP-601(2,3-didehydro-3-deoxy-4-ethynylthymidine) against primary isolates from HIV-2 infected patients experiencing virologic failure. TAF and OBP-601 were tested against twelve primary isolates obtained from nine drug-e...
In Vitro Evaluation of Novel Reverse Transcriptase Inhibitors TAF (Tenofovir Al...
Bártolo, I; Borrego, P; Gomes, P; Gonçalves, F; Caixas, U; Pinto, I; Taveira, NNew antiretroviral drugs are needed to treat HIV-2 infected patients failing therapy. Herein, we evaluate the activity of novel reverse transcriptase inhibitors tenofovir alafenamide (TAF) and OBP-601(2,3-didehydro-3-deoxy-4-ethynylthymidine) against primary isolates from HIV-2 infected patients experiencing virologic failure. TAF and OBP-601 were tested against twelve primary isolates obtained from nine drug-e...
In vitro evaluation of novel reverse transcriptase inhibitors TAF (tenofovir al...
Bártolo, I; Borrego, P; Gomes, P; Gonçalves, F; Caixas, U; Pinto, IV; Taveira, NNew antiretroviral drugs are needed to treat HIV-2 infected patients failing therapy. Herein, we evaluate the activity of novel reverse transcriptase inhibitors tenofovir alafenamide (TAF) and OBP-601(2,3-didehydro-3-deoxy-4-ethynylthymidine) against primary isolates from HIV-2 infected patients experiencing virologic failure. TAF and OBP-601 were tested against twelve primary isolates obtained from nine drug-e...
Accidental Father-to-Son HIV-1 Transmission During the Seroconversion Period
Ezeonwumelu, I; Bártolo, I; Martin, F; Abecasis, A; Campos, T; Romero-Severson, EO; Leitner, T; Taveira, NA 4-year-old child born to an HIV-1 seronegative mother was diagnosed with HIV-1, the main risk factor being transmission from the child's father who was seroconverting at the time of the child's birth. In the context of a forensic investigation, we aimed to identify the source of infection of the child and date of the transmission event. Samples were collected from the father and child at two time points about...
Global, regional, and national age-sex-specific mortality for 282 causes of dea...
Roth, GA; Abate, D; Abate, KH; Abay, SM; Abbafati, C; Abbasi, N; Abbastabar, H; Abd-Allah, L; Abdela, J; Abdelalim, A; Abdollahpour, I; Abdulkader, RSBackground Global development goals increasingly rely on country-specific estimates for benchmarking a nation's progress. To meet this need, the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2016 estimated global, regional, national, and, for selected locations, subnational cause-specific mortality beginning in the year 1980. Here we report an update to that study, making use of newly availa...
Evolution of the Human Immunodeficiency Virus Type 2 Envelope in the First Year...
Rocha, C; Calado, R; Borrego, P; Marcelino, JM; Bártolo, I; Rosado, L; Cavaco-Silva, P; Gomes, P; Família, C; Quintas, A; Skar, H; Leitner, TBackground: Differently from HIV-1, HIV-2 disease progression usually takes decades without antiretroviral therapy and the majority of HIV-2 infected individuals survive as elite controllers with normal CD4+ T cell counts and low or undetectable plasma viral load. Neutralizing antibodies (Nabs) are thought to play a central role in HIV-2 evolution and pathogenesis. However, the dynamic of the Nab response and r...