Introduction and objectives: The use of loop diuretics is central in managing congestion in heart failure (HF), but their impact on prognosis remains unclear. In euvolemic patients, dose reduction is recommended, but there is no recommendation on their discontinuation. This study aims to assess the impact of loop diuretic discontinuation on the prognosis of outpatients with HF with reduced ejection fraction. Me...
Objective: This paper investigates whether deciduous upper molars and lower canines have sexual dimorphic features, exploring these teeth' dimensions and the presence of Zuckerkandl's tubercle and Carabelli's cusp on the first and second upper molars. Design: We analyzed 64 pairs of dental plaster casts from 34 females and 30 males aged between 3 and 12 years. We measured the first and second deciduous upper mo...
Objectives:Angiotensin-converting enzymes' (ACEs) relationship with blood pressure (BP) during childhood has not been clearly established. We aimed to compare ACE and ACE2 activities between BMI groups in a sample of prepubertal children, and to characterize the association between these enzymes' activities and BP.Methods:Cross-sectional study of 313 children aged 8-9 years old, included in the birth cohort Gen...
Photobacterium damselae subsp. piscicida (Phdp) is a Gram-negative fish pathogen with worldwide distribution and broad host specificity that causes heavy economic losses in aquaculture. Although Phdp was first identified more than 50 years ago, its pathogenicity mechanisms are not completely understood. In this work, we report that Phdp secretes large amounts of outer membrane vesicles (OMVs) when cultured in v...
Glioblastoma (GBM) is the most common and aggressive malignant brain tumor in adults. The mainstay of management for GBM is surgical resection, radiation (RT), and chemotherapy (CT). Even with optimized multimodal treatment, GBM has a high recurrence and poor survival rates ranging from 12 to 24 months in most patients. Recently, relevant advances in understanding GBM pathophysiology have opened new avenues for...
Glioblastoma (GBM) is the most common and aggressive malignant brain tumor in adults. The mainstay of management for GBM is surgical resection, radiation (RT), and chemotherapy (CT). Even with optimized multimodal treatment, GBM has a high recurrence and poor survival rates ranging from 12 to 24 months in most patients. Recently, relevant advances in understanding GBM pathophysiology have opened new avenues for...
Objective: To evaluate the potential of the buccolingual dimension of the permanent mandibular canine roots as a sex estimator, using midsagittal cone-beam computed tomography images. Methods: In this retrospective study, 58 Portuguese patients (27 female and 31 male) aged 18-60 years were assessed. The maximum buccolingual dimension of the cervical root was measured in the midsagittal plane through cone-beam c...
Liquid biopsy is an emerging technology with a potential role in the screening and early detection of lung cancer. Several liquid biopsy-derived biomarkers have been identified and are currently under ongoing investigation. In this article, we review the available data on the use of circulating biomarkers for the early detection of lung cancer, focusing on the circulating tumor cells, circulating cell-free DNA,...
Victim identification through dental features is one of the main objectives of forensic dentistry. In circumstances where information regarding antemortem dental records is missing, reconstruction of a biological profile can be useful as a first step toward personal identification. This reconstructive method provides valuable information, namely regarding the individual's ancestry, through the detection and deg...
Federal University of Par?. Graduate Program in Food Science and Technology. Bel?m, PA, Brazil.; Embrapa Food Agroindustry. Rio de Janeiro, RJ, Brazil.; Embrapa Food Agroindustry. Rio de Janeiro, RJ, Brazil.; Embrapa Food Agroindustry. Rio de Janeiro, RJ, Brazil.; Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil.; Federal University of Par?. Graduate Progr...