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Tese (doutorado) - Universidade Federal de Santa Catarina, Centro Tecnológico, Programa de Pós-Graduação em Engenharia Química, Florianópolis, 2016.; A reação química que ocorre entre a hemoglobina e o oxigênio é essencial para a manutenção da homeostase do organismo e sobrevivência das células. Essa reação ocorre em quatro etapas reversíveis e consecutivas, onde o ferro de cada grupo heme que compõe a hemoglob...
Objective: To provide updated information about the preservation of reproductive potential in adult cancer based on the available evidence. Methods: A review of literature published after 2006 was performed using the Medline and PubMed. The evidence was analyzed by specialists from several medical societies; and reflected upon their onclinical practice. After discussion on several working groups, a series of re...
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em Neurociências.; Foram investigadas as ações da melatonina (MEL) contra a lipoperoxidação (LPO) induzida por hidroxil (OH), ascorbil (Asc) e peroxinitrito (ONOO-) em diversos modelos de membranas como lipossomas de fosfatidilcolina (LipPC) e asolecitina (LipASO), microssomas de cérebro (Mi...
Evaluate costs and benefits of rituximab in combination with cyclophosphamide/vincristine/prednisolone chemotherapy regimen (R-CVP), in previously untreated patients with indolent non-Hodgkin lymphoma (NHL), compared to CVP alone from a Portuguese National Health System (NHS) perspective.Cost-effectiveness (Life Years Gained--LYG) and cost-utility analysis (Quality Adjusted Life Years--QALYs) were performed for...
The development of biotechnology drugs represents one of the great advances in medical therapy and it was observed an exponential growth in its use. The resource to these drugs in Oncology and Hematology is no exception and it soon became an essential element of an integrated and directed therapy strategy. The expiry of the first biotechnology drugs patents has opened the door for the development and marketing ...
The administration of cytotoxic chemotherapy may be complicated by the emergence of neutropenia and febrile neutropenia, frequently determining hospital admission and intravenous treatment with broad spectrum antibiotics. Frequently, it is necessary to reduce the dose or to delay the administration of the cytotoxic drugs reducing the relative dose intensity of the chemotherapy regimen. Granulocyte growth factor...
Os linfomas ósseos são pouco frequentes e raramente estão localizados à coluna vertebral, constituindo estas localizações geralmente manifestações secundárias. Os autores apresentam o caso clínico de uma doente de 58 anos de idade, com lombalgia mecânica de 6 semanas de evolução, sem resposta a terapêutica analgésica e anti-inflamatória e sem outras queixas acompanhantes. O estudo complementar revelou a existên...