12 documents found, page 1 of 2

Morphological characterization of mandibular molars in a Portuguese population ...

Forensic Dentistry is the branch of dental medicine that, in a legal context, examines dental evidence by comparing teeth to antemortem dental records, helping the human identification process. In forensic contexts, the study of mandibular teeth may be particularly relevant given that the mandibula, being the only moving part of the skull, can be found in isolation. Human dentition can present several variation...

Real-Life Experience of HER2 (Human Epidermal Growth Factor Receptor 2)-Positiv...

Background: Substantial improvements in survival have been observed in HER2 (human epidermal growth factor receptor 2)-positive (HER2+) inoperable or metastatic breast cancer (advanced breast cancer [ABC]) in recent years, driven by the introduction and widespread use of multiple novel agents. The DESTINY-Breast02 trial compared the efficacy and safety of trastuzumab deruxtecan (T-DXd) in patients with HER2+ AB...

Cancer searching after unprovoked Thromboembolism – still a clinical controversy

Unprovoked Venous thromboembolism (VTE) may be the first sign of an occult cancer. To identify VTE patients at increased risk of cancer and that would have grater benefit from an extensive screening, the RIETE prediction score was developed. We designed an unicentric prospective trial at Senhora da Oliveira Hospital to evaluate the RIETE score performance in identifying the patients at a high-risk of a cancer d...

Current and emerging techniques for diagnosis and MRD detection in AML: a compr...

Acute myeloid leukemia (AML) comprises a group of hematologic neoplasms characterized by abnormal differentiation and proliferation of myeloid progenitor cells. AML is associated with poor outcome due to the lack of efficient therapies and early diagnostic tools. The current gold standard diagnostic tools are based on bone marrow biopsy. These biopsies, apart from being very invasive, painful, and costly, have ...

Sex estimation in children using dental techniques: a review

Caloric restriction rescues yeast cells from alpha-synuclein toxicity through a...

α-Synuclein (SNCA) is a presynaptic protein that is associated with the pathophysiology of synucleinopathies, including Parkinson's disease. SNCA is a naturally aggregation-prone protein, which may be degraded by the ubiquitin-proteasome system (UPS) and by lysosomal degradation pathways. Besides being a target of the proteolytic systems, SNCA can also alter the function of these pathways further, contributing ...

Signalling mechanisms that regulate metabolic profile and autophagy of acute my...

Acute myeloid leukaemia (AML) comprises a heterogeneous group of hematologic neoplasms characterized by diverse combinations of genetic, phenotypic and clinical features representing a major challenge for the development of targeted therapies. Metabolic reprogramming, mainly driven by deregulation of the nutrient-sensing pathways as AMPK, mTOR and PI3K/AKT, has been associated with cancer cells, including AML c...

Recomendações para a preservação do potencial reprodutivo no doente oncológico

Objective: To provide updated information about the preservation of reproductive potential in adult cancer based on the available evidence. Methods: A review of literature published after 2006 was performed using the Medline and PubMed. The evidence was analyzed by specialists from several medical societies; and reflected upon their onclinical practice. After discussion on several working groups, a series of re...

Recomendações para a preservação do potencial reprodutivo no doente oncológico.

Consenso Técnico para a determinação do status da proteína HER2 por imunocitoqu...

A determinação do status da proteína HER2 por imunocitoquímica é uma metodologia fundamental para o diagnóstico, prognóstico e indicação terapêutica no carcinoma da mama, nomeadamente para o encaminhamento terapêutico com Herceptin®/trastuzumab. O estabelecimento desta terapêutica nas vertentes adjuvante ou neoadjuvante, e até em doença metastática, tem vindo a acentuar a importância da determinação do referido...