48 documents found, page 1 of 5
New 4-(N-cinnamoylbutyl)aminoacridines as potential multi-stage antiplasmodial ...
Fonte, Mélanie; Fontinha, Diana; Moita, Diana; Caño-Prades, Omar; Avalos-Padilla, Yunuen; Fernàndez-Busquets, Xavier; Prudêncio, Miguel; Gomes, Paula© 2023 The Authors. Published by Elsevier Masson SAS. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).; A novel family of 4-aminoacridine derivatives was obtained by linking this heteroaromatic core to different trans-cinnamic acids. The 4-(N-cinnamoylbutyl)aminoacridines obtained exhibited in vitro activity in the low- or sub-micromolar range against (i) hep...
Improving the antimycobacterial drug Clofazimine through formation of organic s...
Bento, Clara M.; Silva, Ana Teresa; Mansano, Bruno; Aguiar, Luísa; Teixeira, Cátia; Gomes, Maria Salomé; Gomes, Paula; Silva, Tânia; Ferraz, RicardoThis work reports the synthesis, structural and thermal analysis, and in vitro evaluation of the antimicrobial activity of two new organic salts (OSs) derived from the antimycobacterial drug clofazimine and the fluoroquinolones ofloxacin or norfloxacin. Organic salts derived from active pharmaceutical ingredients (API-OSs), as those herein disclosed, hold promise as cost-effective formulations with improved fea...
Peptide/ionic liquid conjugates to tackle complicated skin infections: antimicr...
Gomes, Ana; Bessa, Lucinda; Fernandes, Iva; Aguiar, Luisa; Ferraz, Ricardo; Monteiro, Cláudia; Martins, Cristina; Mateus, Nuno; Gameiro, PaulaComplicated skin and soft tissue infections (cSSTI) like, e.g., diabeticfoot ulcers (DFU), are severe cases of cutaneous and deeper soft tis-sue infections. Their symptoms are consistent with local polymicro-bial biofilms, which are difficult to eliminate and delay the healing process. The standard-of-care for cSSTI requires oral antibiotics andother measures, often complex and distressing (e.g., amputations). ...
Neuroprotective effects on microglia and insights into the structure–activity r...
Plácido, Alexandra; Amaral, Constança Pais Do; Teixeira, Cátia; Nogueira, Ariane; Brango‐Vanegas, José; Alves Barbosa, Eder; C. Moreira, Daniel© 2022 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited; Tryptophyllins constitute a heterogeneous group of peptides th...
Um pequeno par contra um grande trio
Ferraz, Ricardo; Prudêncio, Cristina; Vieira, Mónica; Gomes, Paula; Teixeira, Cátia“Um pequeno par contra um grande trio” (Two4Three) é um projeto que se propôs combater Malária, Tuberculose e HIV com Líquidos Iónicos (ILs). Um dos grandes problemas de saúde do nosso tempo é a resistência dos agentes infeciosos aos fármacos atualmente disponíveis. Este é um problema particularmente dramático no contexto das “3 grandes doenças” - malária, HIV/SIDA e tuberculose, e em que a constante procura pe...
PEPALHEIRA: Revestimentos edíveis ativos baseados nas proteínas do soro do leit...
Ferraz, Ricardo; Gomes, Paula; Teixeira, Cátia; Prudêncio, CristinaAlheira is a smoked meat from the North of Portugal(“Trás-os-Montes”) that has been named as one of the 7 wonders of Portuguese gastronomy, being a true “business card” of Trás-os-Montes and very appreciated in Portugal and internationally. Due to the economic importance that Alheira represents for the region of Trás-os-Montes, where more than 500 tons are produced annually, there is a growing interest in this ...
New therapeutic approaches based on ionic liquids
Ferraz, Ricardo; Teixeira, Cátia; Prudêncio, Cristina; Teixeira, Dulce; Vieira, Mónica; Gomes, PaulaIonic liquids (ILs) are currently defined as salts (with at least one organic ion) stable above their melting point. They began to be used mainly as solvents, but quickly drew the attention of the Life Sciences, as some of the characteristics of those compounds may be relevant in therapeutic applications. ILs can show more interesting physicochemical properties at the level of active pharmaceutical ingredients ...
The peptide secreted at the water to land transition in a model amphibian has a...
Barbosa, Eder Alves; Plácido, Alexandra; Moreira, Daniel C.; Albuquerque, Lucas; Dematei, Anderson; Silva-Carvalho, Amandda É.; Cabral, Wanessa F.Made available in DSpace on 2022-04-29T08:36:48Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-01-01; In addition to the morphophysiological changes experienced by amphibians during metamorphosis, they must also deal with a different set of environmental constraints when they shift from the water to the land. We found that Pithecopus azureus secretes a single peptide ([M + H]+ = 658.38 Da) at the develo...
The peptide secreted at the water to land transition in a model amphibian has a...
Barbosa, Eder Alves; Plácido, Alexandra; Moreira, Daniel C.; Albuquerque, Lucas; Dematei, Anderson; Carvalho, Amandda É. Silva; Cabral, Wanessa F.In addition to the morphophysiological changes experienced by amphibians during metamorphosis, they must also deal with a different set of environmental constraints when they shift from the water to the land. We found that Pithecopus azureus secretes a single peptide ([M + H]+ = 658.38 Da) at the developmental stage that precedes the onset of terrestrial behaviour. De novo peptide and cDNA sequencing revealed t...
Boosting cosmeceutical peptides: coupling imidazolium-based ionic liquids to pe...
Gomes, Ana; Bessa, Lucinda J.; Fernandes, Iva; Aguiar, Luísa; Ferraz, Ricardo; Monteiro, Cláudia; Martins, M. Cristina L.; Mateus, Nuno; Gameiro, PaulaFollowing our previous reports on dual-action antibacterial and collagenesis-inducing hybrid peptide constructs based on “pentapeptide-4” (PP4, with amino acid sequence KTTKS), whose N-palmitoyl derivative is the well-known cosmeceutical ingredient Matrixyl, herein we disclose novel ionic liquid/PP4 conjugates (IL-KTTKS). These conjugates present potent activity against either antibiotic-susceptible strains or ...