62 documents found, page 1 of 7
OLIVEIRA, Ana Rodrigues – O Amor em Portugal na Idade Média. 1ª edição. Lisboa:...
Teixeira, CátiaReferências bibliográficas Fontes impressas ALMEIDA, Adriana R. de – “Perspetiva sobre a história das emoções. O casamento de D. Leonor de Portugal com o imperador Frederico III (1452)”. In Casamentos da Família Real Portuguesa Diplomacia e Cerimónia. Vol. I. Lisboa: Círculo de Leitores, 2017, pp. 253-287. ALMEIDA, Fortunato de – História da Igreja em Portugal. Nova edição preparada e dirigida por Damião Peres....
Benefits of patient and public involvement in cancer research: literature review
Teixeira, Cátia; Reis, SílviaCurrently, cancer research allows for earlier diagnosis and more effective treatments. The complexity and socio-economic impact of the disease require innovative approaches such as patient and public involvement in research. The aim of this review is to identify the benefits of patients and public involvement in cancer research. The scale for non-systematic reviews, Scale for the Assessment of Narrative Review ...
Repurposing antiplasmodial leads for cancer: Exploring the antiproliferative ef...
Fonte, Mélanie; Rôla, Catarina; Santana, Sofia; Ferraz, Ricardo; Prudêncio, Miguel; Almeida, Joana; Ferraz, Ricardo; Prudêncio, CristinaDrug repurposing and rescuing have been widely explored as cost-effective approaches to expand the portfolio of chemotherapeutic agents. Based on the reported antitumor properties of both trans-cinnamic acids and quinacrine, an antimalarial aminoacridine, we explored the antiproliferative properties of two series of N-cinnamoyl-aminoacridines recently identified as multi-stage antiplasmodial leads. The compound...
Improving the antimycobacterial drug Clofazimine through formation of organic s...
Bento, Clara M.; Silva, Ana Teresa; Mansano, Bruno; Aguiar, Luísa; Teixeira, Cátia; Gomes, Maria Salomé; Gomes, Paula; Silva, Tânia; Ferraz, RicardoThis work reports the synthesis, structural and thermal analysis, and in vitro evaluation of the antimicrobial activity of two new organic salts (OSs) derived from the antimycobacterial drug clofazimine and the fluoroquinolones ofloxacin or norfloxacin. Organic salts derived from active pharmaceutical ingredients (API-OSs), as those herein disclosed, hold promise as cost-effective formulations with improved fea...
Peptide conjugates for the topical treatment of infected wounds
Gomes, Ana; Fernandes, Iva; Bessa, Lucinda; Ferreira, Mariana; Maciel, Joana; Plácido, Alexandra; Teixeira, Cátia; Leal, Ermelindo; Ferraz, RicardoDue to widespread multidrug-resistant (MDR) microbes, efficient treatments for infected wounds are being exhausted.1 The symptoms of wound infection are consistent with local polymicrobial biofilms, which are difficult to eliminate and delay the healing process. The current standard of care requires oral antibiotics and other measures, often complex and distressing (e.g., amputations). A perfect treatment shoul...
New 4-(N-cinnamoylbutyl)aminoacridines as potential multi-stage antiplasmodial ...
Fonte, Mélanie; Fontinha, Diana; Moita, Diana; Caño-Prades, Omar; Avalos-Padilla, Yunuen; Fernàndez-Busquets, Xavier; Prudêncio, Miguel; Gomes, PaulaA novel family of 4-aminoacridine derivatives was obtained by linking this heteroaromatic core to different trans-cinnamic acids. The 4-(N-cinnamoylbutyl)aminoacridines obtained exhibited in vitro activity in the low- or sub-micromolar range against (i) hepatic stages of Plasmodium berghei, (ii) erythrocytic forms of Plasmodium falciparum, and (iii) early and mature gametocytes of Plasmodium falciparum. The mos...
Synthesis od new surface-active ionic liquids derived from antimalarial drugs a...
Silva, Ana Teresa; Oliveira, Isabel; Duarte, Denise; Moita, Diana; Prudêncio, Miguel; Nogueira, Fátima; Teixeira, Cátia; Ferraz, RicardoMalaria is a parasitic disease that occurs mostly in low-income countries, thus its containment or, ultimately, eradication demands new methodologies and synthetic strategies that are simple and inexpensive. Ionic liquids (ILs) may assume a prominent role in this scenario, as they are catching the attention of the Medicinal Chemistry community owing to their intrinsic biological activity and affordable synthesi...
Um pequeno par contra um grande trio
Ferraz, Ricardo; Prudêncio, Cristina; Vieira, Mónica; Gomes, Paula; Teixeira, Cátia“Um pequeno par contra um grande trio” (Two4Three) é um projeto que se propôs combater Malária, Tuberculose e HIV com Líquidos Iónicos (ILs). Um dos grandes problemas de saúde do nosso tempo é a resistência dos agentes infeciosos aos fármacos atualmente disponíveis. Este é um problema particularmente dramático no contexto das “3 grandes doenças” - malária, HIV/SIDA e tuberculose, e em que a constante procura pe...
Peptide-ionic liquid conjugates towards the treatment of skin infections
Gomes, Ana; Bessa, Lucinda; Fernandes, Iva; Teixeira, Cátia; Aguiar, Luísa; Ferraz, Ricardo; Monteiro, Cláudia; Martins, Cristina; Mateus, NunoThe treatment of complicated skin infections, like diabetic foot ulcers and other chronic wounds, are often associated with persistent polymicrobial biofilms that delay and difficult the healing process. The most severe cases culminate in inpatient hospital admission, where infections can be exacerbated by hospital-acquired pathogens, in particular, if caused by the so-called ESKAPE pathogens, for which few eff...
PEPALHEIRA: Revestimentos edíveis ativos baseados nas proteínas do soro do leit...
Ferraz, Ricardo; Gomes, Paula; Teixeira, Cátia; Prudêncio, CristinaAlheira is a smoked meat from the North of Portugal(“Trás-os-Montes”) that has been named as one of the 7 wonders of Portuguese gastronomy, being a true “business card” of Trás-os-Montes and very appreciated in Portugal and internationally. Due to the economic importance that Alheira represents for the region of Trás-os-Montes, where more than 500 tons are produced annually, there is a growing interest in this ...