9 documents found, page 1 of 1

T790M-EGFR mutation frequency in advanced NSCLC patients on progression from a ...

Genetic determinants for prediction of outcome of patients with papillary thyro...

Papillary thyroid carcinoma (PTC) usually presents an excellent prognosis, but some patients present with aggressive metastatic disease. BRAF, RAS, and TERT promoter (TERTp) genes are altered in PTC, and their impact on patient outcomes remains controversial. We aimed to determine the role of genetic alterations in PTC patient outcomes (recurrent/persistent disease, structural disease, and disease-specific mort...

Skeletal muscle–adipose tissue–tumor axis: Molecular mechanisms linking exercis...

Increased visceral adiposity may influence the development of prostate cancer (PCa) aggressive tumors and cancer mortality. White adipose tissue (WAT), usually referred to as periprostatic adipose tissue (PPAT), surrounds the prostatic gland and has emerged as a potential mediator of the tumor microenvironment. Exercise training (ET) induces several adaptations in both skeletal muscle and WAT. Some of these eff...

Wearable Devices for Physical Activity and Healthcare Monitoring in Elderly Peo...

The availability of wearable devices (WDs) to collect biometric information and their use during activities of daily living is significantly increasing in the general population. These small electronic devices, which record fitness and health-related outcomes, have been broadly utilized in industries such as medicine, healthcare, and fitness. Since they are simple to use and progressively cheaper, they have als...

Real-world data from the Portuguese Nivolumab Expanded Access Program (EAP) in ...

OBJECTIVE: The main aim of the study was to evaluate the efficacy and safety profile of Nivolumab, an immune-checkpoint-inhibitor antibody, in advanced, previously treated, Non-Small Cell Lung Cancer (NSCLC) patients, in a real world setting. METHODS: We performed a retrospective, multicentre data analysis of patients who were included in the Portuguese Nivolumab Expanded Access Program (EAP). Eligibility crite...

Clinicopathological features as prognostic predictors of poor outcome in papill...

Papillary thyroid cancer (PTC) has an indolent nature and usually excellent prognosis. Some PTC clinicopathological features may contribute to the development of aggressive metastatic disease. In this work, we want to evaluate PTC clinicopathological features that are presurgical prognostic predictors of patients’ outcomes and find which indicators are more adequate for tailoring surgical procedures and follow-...

Assessment of DNA damage in a group of professional dancers during a 10-month d...

Despite the numerous health benefits of physical activity, some studies reported that increased intensity and duration may induce oxidative stress in several cellular components including DNA. The aim of this study was to assess the level of basal DNA damage as well as oxidative DNA damage in a group of professional dancers before and after a 10-month dancing season. A group of individuals from general populati...

Methodology for analysis of the reactivity of coal fly ash using selective diss...

The use of some additions as cement replacement has played an important role in the amount of clinker reduction. Due to its huge worldwide availability one of the most important and recognised replace agent is the fly ash, but is also estimated that only 30 to 40% of fly ash is used, although there are some challenges to be overcome, such as the reactive potential quantification. Chemical analysis is typically ...

Severity evaluation of ventilated patients at a respiratory intensive care unit...

APACHE II system, is a simple and inexpensive method to evaluate severity of Intensive Care Patients. In a 2 years period (between 1988 and 1990), grading severity using APACHE II system, was performed on 498 consecutive mechanical Ventilated Patients in a Respiratory Intensive Care Unit. APACHE II was higher in COPD patients, but patients with Pneumonia and Organophosphate Poisoning had higher mortality. Corre...