5 documents found, page 1 of 1
Mesenchymal stem cells secretome as a modulator of the neurogenic niche: Basic ...
Salgado, A. J.; Sousa, João Carlos; Costa, B. M.; Pires, A. O.; Mateus-Pinheiro, A.; Teixeira, F. G.; Pinto, Luísa; Sousa, NunoNeural stem cells (NSCs) and mesenchymal stem cells (MSCs) share few characteristics apart from self-renewal and multipotency. In fact, the neurogenic and osteogenic stem cell niches derive from two distinct embryonary structures; while the later originates from the mesoderm, as all the connective tissues do, the first derives from the ectoderm. Therefore, it is highly unlikely that stem cells isolated from one...
Functional gellan gum hydrogels and cell based therapies – A novel therapeutic ...
Gomes, E. D.; Silva, R.; Carvalho, M. M.; Teixeira, F. G.; Leite-Almeida, H.; Gimble, J. M.; Sousa, Nuno; Silva, N. A.; Salgado, A. J.[Excerpt] Introduction: Spinal Cord Injury (SCI) remains one of the most devastating diseases of the Central Nervous System, for which there is still no effective treatment. Multidisciplinary approaches such those presented by tissue engineering concepts hold great promise for SCI treatment. In this sense we previously functionalized a gellan gum hydrogel (GG) with a fibronectin derived peptide - GRGDS.1 Moreov...
Tissue engineering and regenerative medicine: past, present, and future
Salgado, A. J.; Oliveira, J. M.; Matins, A.; Teixeira, F. G.; Silva, N. A.; Neves, N. M.; Reis, R. L.; Sousa, NunoTissue and organ repair still represents a clinical challenge. Tissue engineering and regenerative medicine (TERM) is an emerging field focused on the development of alternative therapies for tissue/organ repair. This highly multidisciplinary field, in which bioengineering and medicine merge, is based on integrative approaches using scaffolds, cell populations from different sources, growth factors, nanomedicin...
Mesenchymal stem cells secretome: a new paradigm for central nervous system reg...
Teixeira, F. G.; Carvalho, M. M.; Sousa, N.; Salgado, A. J.The low regeneration potential of the central nervous system (CNS) represents a challenge for the development of new therapeutic strategies. Mesenchymal stem cells (MSCs) have been proposed as a possible therapeutic tool for CNS disorders. In addition to their differentiation potential, it is well accepted nowadays that their beneficial actions can also be mediated by their secretome. Indeed, it was already dem...
Using the secretome of mesenchymal progenitors of the umbilical cord as a modul...
Teixeira, F. G.; Carvalho, M. M.; Silva, N. A.; Marques, F.; Mesquita, S. D.; Neves, N. M.; Reis, R. L.; Pinto, L.; Sousa, N.; Salgado, A. J.Although it is hypothesized that mesenchymal stem cells’ secretome plays a major role in CNS regeneration, little is known on the mechanisms that regulate these actions. In the present work we aimed to assess if the secretome of a population of MSCs isolated from the WJ of the UC (HUCPVCs) was able to modulate neural/glial survival differentiation and proliferation in in vitro and in vivo models. Two approaches...