18 documents found, page 1 of 2
N-Succinylated canonical vs. dehydropeptides: contrasting self-assembly pathway...
Pereira, Teresa; Carvalho, André F.; Teixeira, Filipe; Magalhães, Andreia Patrícia; Pereira, David M.; Hilliou, L.; Abrunhosa, AnteroLimited mechanical robustness and prompt proteolytic degradation preclude wider biomedical application of supramolecular peptide hydrogels. Low-molecular-weight dehydropeptides represent a promising class of hydrogelators, owing to their enhanced proteolytic stability, high self-assembly propensity, biocompatibility, and tunable rheological and drug-release properties. Herein, we prepared a small library of N-s...
Ciência da Informação, Museologia e Acessibilidade às Coleções na Rede de Museu...
Teixeira, Filipe; Martins, Susana; Carvalho, MilenaThis study investigates the management and communication of information from collections in the Vila Nova de Famalicão Museum Network (RMVNF), focusing on the software used and the instruments for accessing the collections. Additionally, it examines how the RMVNF engaged with the public during periods of confinement due to the COVID-19 pandemic. The methodology used was qualitative, based on semi-structured and...
Enzymatic degradation of ochratoxin A: the role of ultra-pure water
Santos, Joana; Oliveira, Constança; Teixeira, Filipe; Venâncio, Armando; Silva, C.Ochratoxin A (OTA) is a toxic mycotoxin, making its removal from food essential for public health. This study examines OTA degradation by porcine pancreatic lipase (PPL) in ultra-pure water versus buffer systems through in vitro assays and molecular modeling. The results show that PPL fully degrades OTA in ultra-pure water within 7 h at 44 °C, whereas only partial degradation occurs in phosphate buffer. After 4...
meso-Dimethylaminonaphthyl-BODIPY Derivatives as Bioimaging Probes to Monitor I...
Gonçalves, Raquel C. R.; Pinto, Sónia C.S.; Teixeira, Filipe; Belmonte-Reche, Efres; da Silva, Milene Costa; Gallo, Juan; Costa, Susana P. G.Fluorescence-based probes are a powerful tool for monitoring living systems in real time with spatiotemporal precision. 3-Difluoroborodipyrromethene (BODIPY) derivatives are widely used as bioimaging probes due to their excellent photophysical properties, high quantum yields, and chemical stability. In this context, we report two BODIPY-based fluorescent probes for visualizing lysosomes and lipid droplets as we...
Quinoline-based hydrazones for biocide detection: Machine learning-aided design...
Sousa, Rui Pedro Carvalho Lima; Teixeira, Filipe; Costa, Susana P. G.; Figueira, Rita Bacelar; Raposo, M. Manuela M.Antifouling compounds are used as paint components to mitigate biofouling on ships and submerged structures. One of the most known and used antifouling compounds is tributyltin (TBT). However, TBT is toxic to aquatic living beings, causing problems such as reduction of growth and imposex. The development of a TBT chemosensor could be of utter relevance in the building of an in-situ TBT monitoring device. Theref...
Machine learning-assisted optimization of drug combinations in zeolite-based de...
Bertão, Ana Raquel; Teixeira, Filipe; Ivasiv, Viktoriya; Parpot, Pier; Almeida Aguiar, Cristina; Fonseca, A. M.; Bañobre-López, Manuel; Baltazar, FátimaTwo independent artificial neural network (ANN) models were used to determine the optimal drug combination of zeolite-based delivery systems (ZDS) for cancer therapy. The systems were based on the NaY zeolite using silver (Ag+) and 5-fluorouracil (5-FU) as antimicrobial and antineoplastic agents. Different ZDS samples were prepared, and their characterization indicates the successful incorporation of both pharm...
Designing Antitrypanosomal and Antileishmanial BODIPY Derivatives: A Computatio...
Gonçalves, Raquel C. R.; Teixeira, Filipe; Peñalver, Pablo; Costa, Susana P. G.; Morales, Juan C.; Raposo, M. Manuela M.Leishmaniasis and Human African trypanosomiasis pose significant public health threats in resource-limited regions, accentuated by the drawbacks of the current antiprotozoal treatments and the lack of approved vaccines. Considering the demand for novel therapeutic drugs, a series of BODIPY derivatives with several functionalizations at the meso, 2 and/or 6 positions of the core were synthesized and characterize...
A game with a purpose: designing structural modifications in polymyxin B to fac...
Machado, Inês; Miguel Inácio, João; Jorge, Paula; Teixeira, FilipeAntimicrobial resistance (AMR) is a silent pandemic that presents an urgent threat to human health. Recently, polymyxins have been revived as a last-line therapeutic option, despite their toxicity. As such, there is a need for fast and reliable approaches to devise novel polymyxin analogues. In this work, machine learning was employed to devise a semi-quantitative model of the activity of polymyxin-like molecul...
Systematic development of vanadium catalysts for sustainable epoxidation of sma...
Ferraz-Caetano, José; Teixeira, Filipe; Cordeiro, Maria Natália Dias SoeiroThe catalytic epoxidation of small alkenes and allylic alcohols includes a wide range of valuable chemical applications, with many works describing vanadium complexes as suitable catalysts towards sustainable process chemistry. But, given the complexity of these mechanisms, it is not always easy to sort out efficient examples for streamlining sustainable processes and tuning product optimization. In this review...
Machine learning modelling and insights into the structural foundations of poly...
Machado, Inês; Inácio, João; Jorge, Paula; Teixeira, FilipeAntimicrobial resistance (AMR) is a silent pandemic that represents an urgent threat to human health. Unfortunately, the antibiotic development pipeline is slow even though AMR has been escalating uncontrollably fast, namely amongst Gram-negative pathogens. Although out of use until recently due to their toxic side effects, polymyxins have been revived as a last-line therapeutic option since all other antibioti...