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Novel lipids to regulate obesity and brain function: comparing available eviden...

Teixeira, Francisca S.; Costa, Paula T.; Soares, Ana M. S.; Fontes, Ana Luiza; Pintado, Manuela E.; Vidigal, Susana S. M. P.; Pimentel, Lígia L.

Lipid molecules, such as policosanol, ergosterol, sphingomyelin, omega 3 rich phosphatidylcholine, α-tocopherol, and sodium butyrate, have emerged as novel additions to the portfolio of bioactive lipids. In this state-of-the-art review, we discuss these lipids, and their activity against obesity and mental or neurological disorders, with a focus on their proposed cellular targets and the ways in which they prod...


Differential lipid accumulation on HepG2 cells triggered by palmitic and linole...

Teixeira, Francisca S.; Pimentel, Lígia L.; Vidigal, Susana S. M. P.; Azevedo-Silva, João; Pintado, Manuela E.; Rodríguez-Alcalá, Luís M.

Lipid metabolism pathways such as β-oxidation, lipolysis and, lipogenesis, are mainly associated with normal liver function. However, steatosis is a growing pathology caused by the accumulation of lipids in hepatic cells due to increased lipogenesis, dysregulated lipid metabolism, and/or reduced lipolysis. Accordingly, this investigation hypothesizes a selective in vitro accumulation of palmitic and linoleic fa...


Toward sustainable wax extraction from the Saccharum officinarum L. filter cake...

Teixeira, Francisca S.; Costa, Paula T.; Vidigal, Susana S.; Pintado, Manuela; Pimentel, Lígia L.; Rodríguez-Alcalá, Luís M.

Saccharum officinarum L. exploitation and processing result in different byproducts, such as filter cake (FC). This study aimed to establish the most suitable experimental conditions to obtain lipophilic bioactive compounds from FC industrial residues, considering their high efficiency, cost-effectiveness, extraction yield, composition, and physicochemical properties. Results indicated that the most appropriate...


Suitability of solvent-assisted extraction for recovery of lipophilic phytochem...

Teixeira, Francisca S.; Pimentel, Lígia L.; Vidigal, Susana S. M. P.; Costa, Paula T.; Pintado, Manuela E.; Rodríguez-Alcalá, Luís M.

Sugarcane is primarily harvested to meet up to 80% of global sugar demand. Recently, lipids recovered from their biomass (straw and bagasse) have attracted much attention due to their possible utilisation in biofuel production but also by the presence of health-promoting compounds as phytosterols (i.e., improvement of cardiovascular function) or 1-octacosanol (i.e., anti-obesity). Although this fraction is comm...


Lipidomic studies involving steatosis induction using palmitic and linoleic fat...

Teixeira, Francisca S.; Pimentel, Lígia L; Vidigal, Susana S. M. P.; Azevedo-Silva, João; Pintado, Manuela E.; Rodríguez-Alcalá, Luis M.


Phytosterols and novel triterpenes recovered from industrial fermentation copro...

Teixeira, Francisca S.; Vidigal, Susana S. M. P.; Pimentel, Lígia L.; Costa, Paula T.; Tavares‐Valente, Diana; Azevedo‐Silva, João; Pintado, Manuela E.

The unstoppable growth of human population that occurs in parallel with all manufacturing activities leads to a relentless increase in the demand for resources, cultivation land, and energy. In response, currently, there is significant interest in developing strategies to optimize any available resources and their biowaste. While solutions initially focused on recovering biomolecules with applications in food, ...


Predictive oxidative evaluation of lipid samples using differential scanning ca...

Teixeira, Francisca S.; Pimentel, Lígia L.; Vidigal, Susana S. M. P.; Soares, Ana M. S.; Costa, Paula T.; Pintado, Manuela E.; Rodríguez-Alcalá, Luís M.


Suitability for commercial utilization of carnauba and sugarcane waxes through ...

Teixeira, Francisca S.; Vidigal, Susana S. M. P.; Pimentel, Lígia L.; Costa, Paula T.; Pintado, Manuela E.; Rodríguez-Alcalá, Luís M.

In plants, waxes cover the epidermal cells of fruits, petals and leaves, the cuticle act as a physical barrier and signaling trigger against pathogens (i.e., bacteria, yeasts, fungi, virus) and environmental conditions (i.e., wind and rain) [1,2]. Hydrocarbons, wax esters, fatty alcohols, ketones, sterols but also triglycerides [1] have a deep impact in the physicochemical properties of waxes and therefore dete...


Predictive oxidative evaluation of lipid samples using differential scanning ca...

Teixeira, Francisca S.; Pimentel, Lígia L.; Vidigal, Susana S. M. P.; Soares, Ana M. S.; Costa, Paula T.; Pintado, Manuela E.; Rodríguez-Alcalá, Luís M.


Stability study of squalane and hemisqualane derived from synthetic biology

Teixeira, Francisca S.; Pimentel, Lígia L.; Vidigal, Susana S. M. P.; Costa, Paula T.; Pintado, Manuela E.; Rodríguez-Alcalá, Luís M.

Lipids obtained through fermentative processes have emerged as an excellent alternative to produce high-value molecules without compromising natural resources and meeting sustainable requirements [1]. A good example is squalene, the precursor of cholesterol in humans, known by protecting skin against UV radiation. It has been recently shown to reduce side-effects of chemotherapy and is widely used as adjuvant f...


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