44 documents found, page 1 of 5
Resistência à terapêutica com eritropoietina humana recombinante em doentes hem...
Costa, Elísio; Lima, Margarida; Rocha, Susana; Rocha-Pereira, Petronila; Reis, Flávio; Castro, Elisabeth; Teixeira, Frederico; Miranda, VascoCom o objectivo de clarificar o mecanismo de resistência à terapêutica com eritropoietina humana recombinante (EPOhr) em doentes hemodializados, estudamos alterações a ela associada, com particular interesse na inflamação, activação leucocitária, ciclo do ferro, stress oxidativo e lesão eritrocitária. Foram estudados 63 doentes renais crónicos (DRC) em hemodiálise e terapêutica com EPOhr (32 respondedores e 31 ...
Inhibition of bladder tumour growth by sirolimus in an experimental carcinogene...
Parada, Belmiro; Reis, Flávio; Figueiredo, Arnaldo; Nunes, Pedro; Teixeira-Lemos, Edite; Garrido, Patrícia; Sereno, José; Pinto, Rui; Cunha, Maria F.X.To investigate the anticarcinogenic effects of sirolimus 2 mg/kg/day on a rat model of urinary bladder carcinogenesis induced with N-butyl-N(4-hydroxybutyl)nitrosamine (BBN).
Effects of Sitagliptin Treatment on Dysmetabolism, Inflammation, and Oxidative ...
Ferreira, Liliana; Teixeira-de-Lemos, Edite; Pinto, Filipa; Parada, Belmiro; Mega, Cristina; Vala, Helena; Pinto, Rui; Garrido, Patrícia; Sereno, JoséThe purpose of this paper is to evaluate the chronic effect of sitagliptin on metabolic profile, inflammation, and redox status in the Zucker Diabetic Fatty (ZDF) rat, an animal model of obese type 2 diabetes. Diabetic and obese ZDF (fa/fa) rats and their controls (ZDF +/+) were treated during 6 weeks with vehicle (control) and sitagliptin (10mg/kg/bw). Glucose, HbA1c, insulin, Total-c, TGs, IL-1β, TNF-α, CRPhs...
The Place of Dipeptidyl Peptidase-4 Inhibitors in Type 2 Diabetes Therapeutics:...
Godinho, Ricardo; Mega, Cristina; Teixeira-Lemos, Edite; Carvalho, Eugenia; Teixeira, Frederico; Fernandes, Rosa; Reis, FlávioIncretin-based therapies, the most recent therapeutic options for type 2 diabetes mellitus (T2DM) management, can modify various elements of the disease, including hypersecretion of glucagon, abnormal gastric emptying, postprandial hyperglycaemia, and, possibly, pancreatic β cell dysfunction. Dipeptidyl peptidase-4 (DPP-4) inhibitors (gliptins) increase glucagon-like peptide-1 (GLP-1) availability and correct t...
Sitagliptin prevents inflammation and apoptotic cell death in the kidney of typ...
Marques, Catarina; Mega, Cristina; Gonçalves, Andreia; Rodrigues-Santos, Paulo; Lemos, Edite Teixeira de; Teixeira, Frederico; Fontes-Ribeiro, Carlos A.This study aimed to evaluate the efficacy of sitagliptin, a dipeptidyl peptidase IV (DPP-IV) inhibitor, in preventing the deleterious effects of diabetes on the kidney in an animal model of type 2 diabetes mellitus; the Zucker diabetic fatty (ZDF) rat: 20-week-old rats were treated with sitagliptin (10 mg/kg bw/day) during 6 weeks. Glycaemia and blood HbA1c levels were monitored, as well as kidney function and ...
Conversion to sirolimus ameliorates cyclosporine-induced nephropathy in the rat...
Sereno, José; Nunes, Sara; Rodrigues-Santos, Paulo; Vala, Helena; Rocha-Pereira, Petronila; Fernandes, João; Santos-Silva, Alice; Teixeira, FredericoProtocols of conversion from cyclosporin A (CsA) to sirolimus (SRL) have been widely used in immunotherapy after transplantation to prevent CsA-induced nephropathy, but the molecular mechanisms underlying these protocols remain nuclear. This study aimed to identify the molecular pathways and putative biomarkers of CsA-to-SRL conversion in a rat model. Four animal groups (n = 6) were tested during 9 weeks: contr...
Sitagliptin prevents aggravation of endocrine and exocrine pancreatic damage in...
Mega, Cristina; Vala, Helena; Rodrigues-Santos, Paulo; Oliveira, Jorge; Teixeira, Frederico; Fernandes, Rosa; Reis, F.; Lemos, Edite Teixeira deBackground: The purpose of this study was to investigate some of the possible mechanisms underlying the protective effects of a dipeptidyl peptidase IV (DPP-IV) inhibitor, sitagliptin, on pancreatic tissue in an animal model of type 2 diabetes mellitus (T2DM), the Zucker Diabetic Fatty (ZDF) rat, focusing on glycaemic, insulinic and lipidic profiles, as well as, on apoptosis, inflammation, angiogenesis and prol...
Transition from cyclosporine-induced renal dysfunction to nephrotoxicity in an ...
Sereno, José; Rodrigues-Santos, Paulo; Vala, Helena; Rocha-Pereira, Petronila; Alves, Rui; Fernandes, João; Santos-Silva, Alice; Carvalho, EugeniaCyclosporin A (CsA), a calcineurin inhibitor, remain the cornerstone of immunosuppressive regimens, regardless of nephrotoxicity, which depends on the duration of drug exposure. The mechanisms and biomarkers underlying the transition from CsA-induced renal dysfunction to nephrotoxicity deserve better elucidation, and would help clinical decisions. This study aimed to clarify these issues, using a rat model of s...
Transition from Cyclosporine-Induced Renal Dysfunction to Nephrotoxicity in an ...
Sereno, José; Rodrigues-Santos, Paulo; Vala, Helena; Rocha-Pereira, Petronila; Alves, Rui; Fernandes, João; Santos-Silva, Alice; Carvalho, EugéniaCyclosporin A (CsA), a calcineurin inhibitor, remain the cornerstone of immunosuppressive regimens, regardless of nephrotoxicity, which depends on the duration of drug exposure. The mechanisms and biomarkers underlying the transition from CsA-induced renal dysfunction to nephrotoxicity deserve better elucidation, and would help clinical decisions. This study aimed to clarify these issues, using a rat model of s...
Conversion to sirolimus ameliorates cyclosporine-induced nephropathy in the rat...
Sereno, José; Nunes, Sara; Rodrigues-Santos, Paulo; Vala, Helena; Rocha-Pereira, Petronila; Fernandes, João; Santos-Silva, Alice; Teixeira, FredericoProtocols of conversion from cyclosporine A (CsA) to sirolimus (SRL) have been widely used in immunotherapy after transplantation to prevent CsA-induced nephropathy, but the molecular mechanisms underlying these protocols remain nuclear. This study aimed to identify the molecular pathways and putative biomarkers of CsA-to-SRL conversion in a rat model. Four animal groups ( = 6) were teste during 9 weeks: contro...