No abstract available
Cutaneous diseases in returning travelers encompass a wide spectrum of etiologies and often pose diagnostic challenges. We present the cases of a 50-year-old man and a 57-year-old woman who presented with a 3-month history of erythematous, ulcerated plaques with well-defined elevated borders and a necrotic center on the lower limbs that began 3 weeks after returning from vacation in Costa Rica. Cutaneous biopsy...
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Basal cell carcinomas (BCCs) and squamous cell carcinomas (SCCs) are high-incidence, non-melanoma skin cancers (NMSCs). The success of immune-targeted therapies in advanced NMSCs led us to anticipate that NMSCs harbored significant populations of tumor-infiltrating lymphocytes with potential anti-tumor activity. The main aim of this study was to characterize T cells infiltrating NMSCs. Flow cytometry and immuno...
Genital herpes is a sexually transmitted disease with a high global prevalence mainly caused by herpes simplex virus (HSV) type 2, although there has been an increase in the number of cases caused by HSV-1 in recent years. Coinfection by HSV is common in patients with the human immunodeficiency virus (HIV). The atypical clinical presentations of HSV infection are rare, but they are now more frequent in clinical...
Darier disease (DD) is an uncommon autosomal dominant genodermatosis caused by mutations of the ATP2A2 gene, which encodes the sarcoplasmic/endoplasmic reticulum calcium-ATPase isoform 2 (SERCA2). Disfunction of this pump disturbs intracellular Ca2+ signaling, compromising keratinocyte differentiation and intercellular adhesion. Although many therapeutic modalities have been investigated, treatment of DD remain...
A previously healthy 36-year-old Caucasian Portuguese male patient presented to the Dermatology clinic with a 5-day history of multiple painful and itchy papules on his feet. Two weeks earlier, he had travelled to Saint Thomas and Prince Islands, where he played football without wearing shoes. He had been observed four days earlier in another hospital for a similar lesion on his left ankle.
Coronavirus disease 2019 (COVID-19) has affected millions of people since it was declared a pandemic. Three years have passed, but its impact on dermatology practice is still important. We report a case of a 46-year-old woman, Fitzpatrick's phototype III, who presented to our Dermatology Emergency Department with a 3-day history of a painful skin eruption on the face, neck, trunk and upper limbs associated with...
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