4 documents found, page 1 of 1
Long noncoding RNAs: a missing link in osteoporosis
Silva, AM; Moura, SR; Teixeira, JH; Barbosa, MA; Santos, SG; Almeida, MIOsteoporosis is a systemic disease that results in loss of bone density and increased fracture risk, particularly in the vertebrae and the hip. This condition and associated morbidity and mortality increase with population ageing. Long noncoding (lnc) RNAs are transcripts longer than 200 nucleotides that are not translated into proteins, but play important regulatory roles in transcriptional and post-transcript...
The systemic immune response to collagen-induced arthritis and the impact of bo...
Teixeira, JH; Silva, AM; Almeida, MI; Bessa-Gonçalves, M; Cunha, C; Barbosa, MA; Santos, SGRheumatoid arthritis (RA) is a systemic disease that affects the osteoarticular system, associated with bone fragility and increased risk of fractures. Herein, we aimed to characterize the systemic impact of the rat collagen-induced arthritis (CIA) model and explore its combination with femoral bone defect (FD). The impact of CIA on endogenous mesenchymal stem/stromal cells (MSC) was also investigated. CIA indu...
Genetically engineered-MSC therapies for non-unions, delayed unions and critica...
Freitas, J; Santos, SG; Gonçalves, RM; Teixeira, JH; Barbosa, MA; Almeida, MIThe normal bone regeneration process is a complex and coordinated series of events involving different cell types and molecules. However, this process is impaired in critical-size/large bone defects, with non-unions or delayed unions remaining a major clinical problem. Novel strategies are needed to aid the current therapeutic approaches. Mesenchymal stem/stromal cells (MSCs) are able to promote bone regenerati...
Profiling the circulating miRnome reveals a temporal regulation of the bone inj...
Silva, AM; Almeida, MI; Teixeira, JH; Ivan, C; Oliveira, J; Vasconcelos, DM; Neves, N; Ribeiro-Machado, C; Cunha, C; Barbosa, MA; Calin, G; Santos, SGBone injury healing is an orchestrated process that starts with an inflammatory phase followed by repair and remodelling of the bone defect. The initial inflammation is characterized by local changes in immune cell populations and molecular mediators, including microRNAs (miRNAs). However, the systemic response to bone injury remains largely uncharacterized. Thus, this study aimed to profile the changes in the ...