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Real-Life Experience of HER2 (Human Epidermal Growth Factor Receptor 2)-Positiv...

Bizarro, Rita; Pazos, Isabel; Teixeira, Alexandra; Pereira, Margarida; Gonçalves, Joana; Abreu, Catarina; Ferreira, Rita; Oliveira, Sónia

Background: Substantial improvements in survival have been observed in HER2 (human epidermal growth factor receptor 2)-positive (HER2+) inoperable or metastatic breast cancer (advanced breast cancer [ABC]) in recent years, driven by the introduction and widespread use of multiple novel agents. The DESTINY-Breast02 trial compared the efficacy and safety of trastuzumab deruxtecan (T-DXd) in patients with HER2+ AB...

Date: 2025 | Origin: Repositório do Centro Hospitalar de Lisboa Central, EPE

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Um caso de Carcinoma do Pulmão de Não Pequenas Células EGFR

Campos, Sofia; Custódio, Catarina; Felizardo, Margarida; Calha, Jaime; Madureira, Rosa Maria; Teixeira, José Alberto

Background: EGFR mutation is the most frequent in Non-Small Cell Lung Cancer and occurs mainly in women and non-smoking patients. Clinical case: We present the case of a 51-year-old female, former light smoker, diagnosed with lung adenocarcinoma in 2014, in stage IB. She underwent surgery and adjuvant therapy. She recurred after two years with metas-tatic lung and bone disease, with EGFR exon 21 mutation. Thera...

Date: 2024 | Origin: THORAC (Thoracic Cancer Journal)

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