2 documents found, page 1 of 1
Type I IFN induces IL-10 production in an IL-27-independent manner and blocks r...
McNab, Finlay W.; Ewbank, John; Howes, Ashleigh; Teixeira, Lucia de Fatima Moreira; Martirosyan, Anna; Ghilardi, Nico; Saraiva, Margarida; O’Garra, AnneTuberculosis, caused by the intracellular bacterium Mycobacterium tuberculosis, currently causes ~1.4 million deaths per year, and it therefore remains a leading global health problem. The immune response during tuberculosis remains incompletely understood, particularly regarding immune factors that are harmful rather than protective to the host. Overproduction of the type I IFN family of cytokines is associate...
Mycobacterium tuberculosis strains are differentially recognized by TLRs with a...
Carmona, J. A.; Cruz, Andrea; Teixeira, Lucia de Fatima Moreira; Sousa, Carole Lara Veiga de; Sousa, Jeremy Nicolas Carvalho; Osório, Nuno S.Tuberculosis associates with a wide spectrum of disease outcomes. The Beijing (Bj) lineage of Mycobacterium tuberculosis (Mtb) is suggested to be more virulent than other Mtb lineages and prone to elicit non-protective immune responses. However, highly heterogeneous immune responses were reported upon infection of innate immune cells with Bj strains or stimulation with their glycolipids. Using both in vitro and...