4 documents found, page 1 of 1
The Initial Journey of Patients with Metastatic Pancreatic Cancer (PaCTO Projec...
Barros, AG; Mansinho, H; Couto, N; Teixeira, MR; Tonin, FS; Francisco, R; Duarte-Ramos, FIntroduction: We aimed to characterize the initial healthcare journey of metastatic pancreatic ductal adenocarcinoma (mPDAC) patients in Portugal, including healthcare provision and factors affecting therapeutic decisions, namely BRCA mutations testing. Methods: This is a descriptive cross-sectional, web-based survey using a convenience sampling approach. Portuguese oncologists and pathologists that routinely w...
Case Report: Pheochromocytoma and Synchronous Neuroblastoma in a Family With He...
Duarte, DB; Ferreira, L; Santos, AP; Costa, C; Lima, J; Santos, C; Afonso, M; Teixeira, MR; Carvalho, R; Cardoso, MHIntroduction: Pheochromocytomas are rare catecholamine-producing neuroendocrine tumours arising from chromaffin cells of the adrenal medulla or extra-adrenal sympathetic paraganglia. Recent studies have indicated that up to 40% of pheochromocytomas could be attributable to an inherited germline variant in an increasing list of susceptibility genes. Germline variants of the MYC-associated factor (MAX) gene have ...
Tumor Testing for Somatic and Germline BRCA1/BRCA2 Variants in Ovarian Cancer P...
Peixoto, A; Pinto, P; Guerra, J; Pinheiro, M; Santos, C; Pinto, C; Santos, R; Escudeiro, C; Bartosch, C; Canário, R; Barbosa, A; Gouveia, A; Petiz, ADeleterious variants in the BRCA1/BRCA2 genes and homologous recombination deficiency (HRD) status are considered strong predictors of response to poly (ADP-ribose) polymerase (PARP) inhibitors (PARPi). The introduction of PARPi in clinical practice for the treatment of patients with advanced ovarian cancer imposed changes in the molecular diagnosis of BRCA1/BRCA2 variants. BRCA1/BRCA2 tumor testing by next-gen...
Intraepidermal Epidermotropic Metastatic Melanoma: a Clinical and Histopatholog...
Lestre, S; João, A; Ponte, P; Peixoto, A; Vieira, J; Teixeira, MR; Fidalgo, AThe distinction between primary melanoma and melanoma metastatic to the skin has major prognostic implications. We report a case of a 67-year-old male with a diagnosis of a superficial spreading melanoma (stage IB) rendered 6 years earlier who presented clinically with an atypical nevus on his left thigh. Histopathological examination showed an intraepidermal melanocytic proliferation that was interpreted as me...