2 documents found, page 1 of 1
Role of regulatory T cells in irinotecan-induced intestinal mucositis
Fernandes, Camila; Wanderley, Carlos Wagner Souza; Silva, Camila Meireles Souza; Muniz, Heitor Amorim; Teixeira, Maraiza AlvesIntestinal mucositis (IM) is a common side effect of irinotecan-based chemotherapy. The involvement of inflammatory mediators, such as TNF-α, IL1-β, IL-18 and IL-33, has been demonstrated. However, the role of adaptive immune system cells, whose activation is partially regulated by these cytokines, is yet unknown. Thus, we investigated the role of regulatory T cells (Tregs) in irinotecan-induced IM. C57BL/6 mic...
Papel de receptores CXCR2 na mucusite intestinal induzida por irinotecano
Teixeira, Maraiza AlvesIntroduction: Irinotecan is an anticancer agent used in first and second line treatment protocols for colorectal cancer. However, a major side effect associated with irinotecan, intestinal mucositis, has negatively impacted on patient’s quality of life and limiting the therapeutic outcome. The literature reports the involvement of several inflammatory mediators in the pathogenesis of intestinal mucositis, inclu...