7 documents found, page 1 of 1
Hydrogel bioinks of alginate and curcumin-loaded cellulose ester-based particle...
Carvalho, João P. F.; Teixeira, Maria C.; Lameirinhas, Nicole S.; Matos, Filipe S.; Luís, Jorge L.; Pires, Liliana; Oliveira, Helena; Oliveira, Martinho3D bioprinting is a versatile technique that allows the fabrication of living tissue analogs through the layer-by-layer deposition of cell-laden biomaterials, viz. bioinks. In this work, composite alginate hydrogel-based bioinks reinforced with curcumin-loaded particles of cellulose esters (CEpCUR) and laden with human keratinocytes (HaCaT) are developed. The addition of the CEpCUR particles, with sizes of 740 ...
A guide to polysaccharide-based hydrogel bioinks for 3D bioprinting applications
Teixeira, Maria C.; Lameirinhas, Nicole S.; Carvalho, João P. F.; Silvestre, Armando J. D.; Vilela, Carla; Freire, Carmen S. R.Three-dimensional (3D) bioprinting is an innovative technology in the biomedical field, allowing the fabrication of living constructs through an approach of layer-by-layer deposition of cell-laden inks, the so-called bioinks. An ideal bioink should possess proper mechanical, rheological, chemical, and biological characteristics to ensure high cell viability and the production of tissue constructs with dimension...
Alginate-lysozyme nanofibers hydrogels with improved rheological behavior, prin...
Teixeira, Maria C.; Lameirinhas, Nicole S; Carvalho, João P F; Valente, Bruno F A; Luís, Jorge; Pires, Liliana; Oliveira, Helena; Oliveira, MartinhoIn this study, alginate nanocomposite hydrogel bioinks reinforced with lysozyme nanofibers (LNFs) were developed. Alginate-LNF (A-LNF) suspensions with different LNF contents (1, 5 and 10 wt.%) were prepared and pre-crosslinked with 0.5% (w/v) CaCl2 to formulate A-LNF inks. These inks exhibit proper shear-thinning behavior and good recovery properties (~90%), with the pre-crosslinking step playing a crucial rol...
Nanofibrillated cellulose/gellan gum hydrogel-based bioinks for 3D bioprinting ...
Lameirinhas, Nicole S.; Teixeira, Maria C.; Carvalho, João P.F.; Valente, Bruno F.A.; Pinto, Ricardo J.B.; Oliveira, Helena; Luís, Jorge L.The development of suitable bioinks is an important research topic in the field of three-dimensional (3D) bioprinting. Herein, novel hydrogel-based bioinks composed of nanofibrillated cellulose (NFC) and gellan gum (GG) in different NFC/GG mass proportions (90:10, 80:20, 70:30, and 60:40) were developed and characterized. The increase in the content of GG, as well as its combination with NFC, enhanced their rhe...
Nanomedicines for the Delivery of Antimicrobial Peptides (AMPs)
Teixeira, Maria C.; Carbone, Claudia; Sousa, Maria do Céu; Espina, Marta; Garcia, Maria L.; Sanchez-Lopez, ElenaMicrobial infections are still among the major public health concerns since several yeasts and fungi, and other pathogenic microorganisms, are responsible for continuous growth of infections and drug resistance against bacteria. Antimicrobial resistance rate is fostering the need to develop new strategies against drug-resistant superbugs. Antimicrobial peptides (AMPs) are small peptide-based molecules of 5-100 ...
Nanomedicines for the delivery of antimicrobial peptides (AMPs)
Teixeira, Maria C.; Carbone, Claudia; Sousa, Maria C.; Espina, Marta; Garcia, Maria L.; Sanchez-Lopez, Elena; Souto, Eliana B.Microbial infections are still among the major public health concerns since several yeasts and fungi, and other pathogenic microorganisms, are responsible for continuous growth of infections and drug resistance against bacteria. Antimicrobial resistance rate is fostering the need to develop new strategies against drug-resistant superbugs. Antimicrobial peptides (AMPs) are small peptide-based molecules of 5–100 ...
New nanotechnologies for the treatment and repair of skin burns infections
Souto, Eliana B.; Ribeiro, André F.; Ferreira, Maria I.; Teixeira, Maria C.; Shimojo, Andrea A. M.; Soriano, José L.; Naveros, Beatriz C.Burn wounds are highly debilitating injuries, with significant morbidity and mortality rates worldwide. In association with the damage of the skin integrity, the risk of infection is increased, posing an obstacle to healing and potentially leading to sepsis. Another limitation against healing is associated with antibiotic resistance mainly due to the use of systemic antibiotics for the treatment of localized in...