The initial encounter of Leishmania with its host’s immune system is important in the outcome of infection. Previous studies have shown that PBMCs from healthy volunteers (HV) exposed to Leishmania differ in IFN-γ production. We have expanded such observations evaluating the profi le and kinetics of cytokines (IFN-γ, IL-12p70, IL-10, IL-13), chemokines (CCL5, CCL3, CCL4, CXCL10), and chemokine receptors (CCR1,C...
The effect of a quinone fraction (QF) isolated from the heartwood of Auxemma oncocalyx Taub. was investigated in vitro and in vivo on Leishmania braziliensis . Although QF (1-10 μ g/mL) showing marked in vitro anti- Leishmania activity (81 to 94%), the oral treatment with the compound did not protect hamsters against progressive L. braziliensis infection. When QF was administered intraperitoneally (20 mg/kg) th...
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Recruitment of a specific cell population after Leishmania infection can influence the outcome of the disease. Cellular migration in response to Leishmania or vector saliva has been reported in air pouch model, however, cellular migration induced by Leishmania associated with host's blood and vector saliva in this model has not been described. Herein we investigated cellular migration into air pouch of hamster ...
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p. 977-984; Submitted by JURANDI DE SOUZA SILVA (jssufba@hotmail.com) on 2012-11-08T18:46:05Z No. of bitstreams: 1 1-s2.0-S1286457904001856-main.pdf: 320965 bytes, checksum: aef854a2cfd36c43568ef089a238616a (MD5); Made available in DSpace on 2012-11-08T18:46:05Z (GMT). No. of bitstreams: 1 1-s2.0-S1286457904001856-main.pdf: 320965 bytes, checksum: aef854a2cfd36c43568ef089a238616a (MD5) Previous issue date: 2004...
Antimonials, drugs of choice for the treatment of leishmaniasis, provide good results but have side effects and cases of resistance have been reported. In recent years, there has been an increase in the search for new antiparasitic drugs developed from plants extracts. This study aims to evaluate the leishmanicidal effects, both in vitro and in vivo, of two chemicals isolated from medicinal plants, tymol and la...