2 documents found, page 1 of 1
Saccharomyces cerevisiae cells lacking the zinc vacuolar transporter Zrt3 displ...
Terra-Matos, Joana; Teixeira, Marta Oliveira; Pereira, Cátia Sofia Santos; Noronha, Henrique; Domingues, Lucília; Sieiro, Carmen; Gerós, H.Yeast-based bioethanol production from lignocellulosic hydrolysates (LH) is an attractive and sustainable alternative for biofuel production. However, the presence of acetic acid (AA) in LH is still a major problem. Indeed, above certain concentrations, AA inhibits yeast fermentation and triggers a regulated cell death (RCD) process mediated by the mitochondria and vacuole. Understanding the mechanisms involved...
Drug targeting of inflammatory bowel diseases by biomolecules
Antunes, Joana Isabel Costa; Seabra, Catarina Leal; Domingues, Joana Margarida; Teixeira, Marta Oliveira; Nunes, Cláudia; Costa-Lima, Sofia AntunesInflammatory bowel disease (IBD) is a group of disabling, destructive and incurable immune-mediated inflammatory diseases comprising Crohn's disease (CD) and ulcerative colitis (UC), disorders that are highly prevalent worldwide and demand a large investment in healthcare. A persistent inflammatory state enables the dysfunction and destruction of healthy tissue, hindering the initiation and endurance of wound h...