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Unveiling the angiogenic effects of cannabinoids: Enhancers or inhibitors?
Maia, J; Fonseca, BM; Teixeira, N; Georgina Correia da SilvaCannabinoids are compounds found in the cannabis sativa plant. Cannabinoids, such as delta-9tetrahydrocannabinol (THC) and cannabidiol (CBD), have potential therapeutic benefits in various medical conditions. Some can activate the cannabinoid receptors type-1 and -2 (CB1 and CB2), that are part of the endocannabinoid system (ECS), alongside the endocannabinoids and their metabolic enzymes. The ECS regulates phy...
Vaccines in Congenital Toxoplasmosis: Advances and Perspectives
Barros, M; Teixeira, D; Vilanova, M; Correia, A; Teixeira, N; Borges, MCongenital toxoplasmosis has a high impact on human disease worldwide, inducing serious consequences from fetus to adulthood. Despite this, there are currently no human vaccines available to prevent this infection. Most vaccination studies against Toxoplasma gondii infection used animal models in which the infection was established by exogenous inoculation. Here, we review recent research on potential T. gondii...
Toxoplasma gondii infection reduces serum progesterone levels and adverse effec...
Brito, C; M, Silva, T; M Castro, M; Wyrwas, W; Oliveira, B; M, Fonseca, B; Oliveira, P; W, Roberts, C; Teixeira, N; Borges, MAims: Pregnant BALB/c mice infected with a Toxoplasma gondii type II strain were used to determine how pregnancy interferes with the development of maternal immunity to T gondii and how infection disrupts pregnancy and foetal development. Methods: Maternal and foetal parasite loads were assessed by amplification of T gondii SAG1 using qPCR. Adverse effects of infection were evaluated on foetal-placental develop...
Uterine Rupture at 18 Weeks of Pregnancy in the Context of Malformed Uterus
Vale-Fernandes, E; Teixeira, N; Cadilhe, A; Rocha, MJBirth defects of the female genital tract are relatively common and often asymptomatic. Despite the pregnancy outcome can be favorable, adverse obstetric outcomes are described in women with uterine malformations. The authors report the case of an obstetric emergency which enhances the possibility of a very adverse and rare outcome of uterine rupture in a left hemi-cavity of a bicornuate uterus away from the te...
Establishment of the Chemical Equilibria of Different Types of Pyranoanthocyani...
Luis Cruz; Petrov, V; Teixeira, N; Nuno Mateus; Pina, F; Victor de FreitasThe chemical equilibria of the pyranomalvidin-3-glucosides linked to (+)-catechin, (-)-epicatechin, and catechol moieties (and the respective coumaroylglucoside Compounds) were established by means of UV-vis spectroscopy. The conjugated double bonds among pyranic rings C and D provide a higher electronic delocalization that prevents the nucleophilic attack of water at position 2. Consequently, besides flavylium...