11 documents found, page 1 of 2

Sustainable chitosan packaging films: Green tea polyphenolic extraction strateg...

In this work, an alternative approach towards the use of a ternary natural deep eutectic solvent (ChCl/glycerol/lactic acid: NADES-3) as an environmentally friendly medium for the extraction of polyphenolic compounds from green tea (GT) was investigated. The ternary NADES have a higher capacity of polyphenolic extraction in comparison with the other two binary NADES (NADES-1 and NADES-2, ChCl/glycerol and ChCl/...

Polyphenol extraction by deep eutectic solvent for valorisation of portuguese g...

The current demand for antioxidant active packaging, that is achieved by introducing antioxidants into food packaging material, is increasing due to both the unquestionable advantages compared to the addition of antioxidants directly to the food and the tendency to consume healthy and fresh products. When developing active packaging materials, research has been focused on natural and biodegradable polymers (suc...

The anti-cancer potential of crotoxin in estrogen receptor-positive breast canc...

The endocannabinoid 2-arachidonoylglycerol promotes endoplasmic reticulum stres...

Proliferation, differentiation and apoptosis of trophoblast cells are required for normal placental development. Impairment of those processes may lead to pregnancy-related diseases. Disruption of endoplasmic reticulum (ER) homeostasis has been associated with several reproductive pathologies including recurrent pregnancy loss and preeclampsia. In the unfolded protein response (UPR), specific ER-stress signalli...

Cannabis and cannabinoids for medical use

Cannabis derivatives, like other natural products, have been used for medicinal purposes for millennia. Although the advent of molecular biology and computational chemistry has reduced the use of natural products as a source of therapeutic agents, nature continues to influence the emergence of new drug candidates. Cannabis and its products (hashish, marijuana) contain more than 500 compounds, including more tha...

The role of soybean extracts and isoflavones in hormone-dependent breast cancer...

New steroidal aromatase inhibitors: biological effects in hormone-dependent bre...

Aromatase inhibitors (AIs) are currently used as a first-line therapeutic approach for hormone-dependent (ER+) breast tumors in postmenopausal women, the most common type of cancer diagnosed among women, in which estrogen plays a key role. Aromatase is the enzyme responsible for estrogen biosynthesis, so its inhibition results in estrogen suppression, avoiding tumor growth. However, the existence of side-effect...

Chemical investigations on the spiny sea-star Marthasterias glacialis collected...

Marine organisms are increasingly regarded as a promising source of bioactive molecules for human pharmacotherapy, being used in conditions such as cancer, inflammation, infection and pain.Marthasterias glacialis, also known as the spiny sea-star, is an echinoderm common in the Portuguese coast, however little information is available regarding its chemical constituents.In this work, the chemistry of this organ...

New steroidal 17b-carboxy derivatives present anti-5a-reductase activity and an...

The androgens testosterone (T) and dihydrotestosterone (DHT), besides playing an important role in prostate development and growth, are also responsible for the development and progression of benign prostate hyperplasia (BPH) and prostate cancer. Therefore, the actions of these hormones can be antagonized by preventing the irreversible conversion of T into DHT by inhibiting 5a-reductase (5a-R). This has been a ...

Evaluation of cheese authenticity and proteolysis by HPLC and urea-polyacrylami...

Chromatographic and electrophoretic methods have been established as useful tools in characterising cheese ripening and in the detection of milk adulteration. The purpose of this work was to evaluate casein proteolysis of cheeses made from bovine, ovine or mixtures of bovine and ovine milks, as well as ovine cheese authenticity, for 30 days of ripening by HPLC and urea–polyacrylamide gel electrophoresis. Comple...