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Natural compounds: co-delivery strategies with chemotherapeutic agents or nucle...
Teixeira, Patrícia V.; Fernandes, Eduarda; Soares, Telma B.; Adega, Filomena; Lopes, Carla M.; Lúcio, M.Cancer is one of the leading causes of death, and latest predictions indicate that cancer- related deaths will increase over the next few decades. Despite significant advances in conventional therapies, treatments remain far from ideal due to limitations such as lack of selectivity, non-specific distribution, and multidrug resistance. Current research is focusing on the development of several strategies to impr...
pH-responsive hybrid nanoassemblies for cancer treatment: formulation developme...
Teixeira, Patrícia V.; Adega, Filomena; Martins-Lopes, Paula; Machado, Raul; Lopes, Carla M.; Lúcio, M.Current needs for increased drug delivery carrier efficacy and specificity in cancer necessitate the adoption of intelligent materials that respond to environmental stimuli. Therefore, we developed and optimized pH-triggered drug delivery nanoassemblies that exhibit an increased release of doxorubicin (DOX) in acidic conditions typical of cancer tissues and endosomal vesicles (pH 5.5) while exhibiting significa...
pH-responsive hybrid nanoassemblies for cancer treatment: formulation developme...
Teixeira, Patrícia V.; Adega, Filomena; Martins-Lopes, Paula; Machado, Raul; Lopes, Carla Martins; Lúcio, MarleneCurrent needs for increased drug delivery carrier efficacy and specificity in cancer necessitate the adoption of intelligent materials that respond to environmental stimuli. Therefore, we developed and optimized pH-triggered drug delivery nanoassemblies that exhibit an increased release of doxorubicin (DOX) in acidic conditions typical of cancer tissues and endosomal vesicles (pH 5.5) while exhibiting significa...
Natural compounds: co-delivery strategies with chemotherapeutic agents or nucle...
Teixeira, Patrícia V.; Fernandes, Eduarda; Soares, Telma B.; Adega, Filomena; Lopes, Carla Martins; Lúcio, MarleneCancer is one of the leading causes of death, and latest predictions indicate that cancer- related deaths will increase over the next few decades. Despite significant advances in conventional therapies, treatments remain far from ideal due to limitations such as lack of selectivity, non-specific distribution, and multidrug resistance. Current research is focusing on the development of several strategies to impr...