2 documents found, page 1 of 1
The Barretos Cancer Hospital Animal Facility: implementation and results of a d...
Teixeira, Silvia A.; Luzzi, Mayara de Cassia; Martin, Ana Carolina Baptista Moreno; Duarte, Terence Teixeira; Leal, Mônica de OliveiraThe Barretos Cancer Hospital Animal Facility (BCHAF) is a unique facility in Brazil exclusively dedicated to working with animal models for cancer research. In this article, we briefly present our modern facility and the main experiments performed, focusing on mutant strains of mice (PTCH-knockout and <i>Apc<sup>Min</sup></i> mice), xenograft models, and patient-derived xenografts (PDXs). Our results show the p...
The Carbonic Anhydrase Inhibitor E7070 Sensitizes Glioblastoma Cells to Radio- ...
Teixeira, Silvia A.; Viapiano, Mariano S.; Andrade, Augusto F.; Nandhu, Mohan S.; Pezuk, Julia A.; Bidinotto, Lucas T. [UNESP]; Suazo, Veridiana K.Made available in DSpace on 2021-06-25T11:03:47Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-01-01; Glioblastomas (GBMs), the most common and lethal primary brain tumor, show inherent infiltrative nature and high molecular heterogeneity that make complete surgical resection unfeasible and unresponsive to conventional adjuvant therapy. Due to their fast growth rate even under hypoxic and acidic conditi...