28 documents found, page 1 of 3

Liposomal formulations for efficient delivery of a novel, highly potent pyrimid...

Background/Objectives: Cancer is one of the deadliest diseases worldwide. Despite the existing treatments, the adverse side effects and the increasing drug resistance to the current therapies lead to a reduced quality of life for patients and poor prognosis. The pyrimido[5,4-d]pyrimidine compound (PP) was identified as a promising new anticancer drug due to its potent activity against colorectal and triple-nega...

Hydrazides as powerful tools in medicinal chemistry: synthesis, reactivity, and...

The increase in drug resistance and the high toxicity of current drugs have inspired the scientific community to develop new drugs for various diseases. Hydrazides have become an attractive functional group to easily obtain a plethora of novel compounds with a broad range of biological activities. This review, which contains studies in the literature from the previous five years, focuses on the synthesis method...

Translation and Cultural Adaptation of the ISTH-Bleeding Assessment Tool to Eur...

Introduction: A distinctive bleeding history is the first diagnostic stage of congenital hemorrhagic diseases. Furthermore, since it is in fact an assessment of the patient’s phenotype, it is not a (mere) complementary diagnostic method or test - it is an integral and intrinsic step to establish the patient’s clinical history, which is a medical act. The International Society on Thrombosis and Haemostasis-Bleed...

Albumin/Hyaluronic acid gel nanoparticles loaded with a pyrimidine-based drug f...

A pyrimidine-based compound (PP) was recently found to be a promising anticancer agent for colorectal and breast cancers. However, this compound exhibited low selectivity and poor water solubility. To address these challenges, albumin gel nanoparticles were used, where the gel matrix is formed by cross-linking of BSA molecules, allowing for a high concentration of this hydrophobic drug to be carried with no cyt...

Noite europeia dos investigadores em Armamar: palco da ciência em ambientes rurais

Manifestações Oculares da Síndrome de Alport: Casuística de um Centro Hospitala...

INTRODUÇÃO: A síndrome de Alport (SA) é uma doença hereditária que ocorre por variantes nos genes COL4A3/4/5. Padrões de hereditariedade incluem ligado ao X (SALX), autossómica dominante (SAAD) ou recessiva (SAAR) e digénica. As alterações do colagénio tipo IV α3α4α5 podem comprometer a estrutura da membrana basal do rim, cóclea e olho. As manifestações oculares incluem erosões corneanas recorrentes, lenticone,...

Noite europeia dos investigadores de Armamar: palco da ciência em ambientes rurais

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Em torno do imaginário «Do Lapedo a Santa Eufémia» — experiências criativas com...

Este texto incide sobre os processos cíclicos de ação e investigação desenvolvidos no âmbito do projeto de intervenção e animação artísticas intitulado «Do Lapedo a Santa Eufémia». Caracteriza-se o projeto desenvolvido com as crian ças de um Jardim de Infância de Santa Eufémia, em Leiria, com a finalidade de reforçar o entrosamento entre os membros da comunidade e o reconhecimento do próprio património local. R...

Do Lapedo a Santa Eufémia – um projeto de intervenção e animação artísticas

2-Aryladenine derivatives as a potent scaffold for adenosine receptor antagonis...

A set of 2-aryl-9-H or methyl-6-morpholinopurine derivatives were synthesized and assayed through radioligand binding tests at human A<inf>1</inf>, A<inf>2A</inf>, A<inf>2B</inf>, and A<inf>3</inf> adenosine receptor subtypes. Eleven purines showed potent antagonism at A<inf>1</inf>, A<inf>3</inf>, dual A<inf>1</inf>/A<inf>2A</inf>, A<inf>1</inf>/A<inf>2B</inf>, or A<inf>1</inf>/A<inf>3</inf> adenosine receptor...