Encontrados 23 documentos, a visualizar página 1 de 3
Circulating levels of neurotrophic factors are unchanged in patients with Parki...
Rocha,Natalia Pessoa; Ferreira,João Paulo Sampaio; Scalzo,Paula Luciana; Barbosa,Izabela Guimarães; Souza,Mariana Soares de; Christo,Paulo PereiraABSTRACT There is great evidence linking neurotrophic factor (NF) dysfunction with Parkinson's disease (PD) pathophysiology. This study was conducted to evaluate plasma levels of NFs and their possible associations with clinical symptoms in PD. For this purpose, 40 PD patients and 25 controls were subjected to a clinical evaluation and peripheral blood draw. Plasma levels of brain-derived neurotrophic factor (B...
Estrogen receptor-alpha gene XbaI A > G polymorphism influences short-term c...
Chaves,Amanda Caroline Silva; Fraga,Vanessa Gomes; Guimarães,Henrique Cerqueira; Teixeira,Antonio Lucio; Barbosa,Maira TonidandelABSTRACT This prospective study aimed to evaluate the influence of the -351A/G XbaI polymorphism in the estrogen receptor-alpha (ESR-1) gene on global cognitive scores of a community sample of healthy oldest-old individuals within one year of follow up. Methods The individuals were categorized in two groups according to the presence or absence of cognitive decline. Cognitive data were related to genetic informa...
Persistent Sydenham’s chorea is not associated with sustained lymphocyte dysfun...
Torres,Karen Cecília de Lima; Rocha,Natália Pessoa; Rezende,Vítor Bortolo de; Dutra,Walderez Ornelas; Gollob,Kenneth John; Cardoso,FranciscoThe mechanisms involved in the symptoms of Sydenham’s chorea (SC) remain obscure. Taking into account the autoreactive antibody-mediated hypothesis of SC pathogenesis, the persistence of chorea may be associated with increased levels of B1 lymphocytes and other lymphocyte subsets. We evaluated lymphocyte subsets, including B1 and T cells, in patients with remitted (RSC) and persistent (PSC) SC by flow cytometry...
Revisiting the neuropsychiatry of Huntington's disease
Teixeira,Antonio Lucio; Souza,Leonardo Cruz de; Rocha,Natalia Pessoa; Furr-Stimming,Erin; Lauterbach,Edward C.ABSTRACT Huntington's disease (HD) is an autosomal dominant neurodegenerative disease classified under the choreas. Besides motor symptoms, HD is marked by cognitive and behavioral symptoms, impacting patients' functional capacity. The progression of cognitive impairment and neuropsychiatric symptoms occur in parallel with neurodegeneration. The nature of these symptoms is very dynamic, and the major clinical c...
Features associated with cognitive impairment and dementia in a community-based...
Guimarães,Henrique Cerqueira; Cascardo,Jorge Luiz; Beato,Rogério Gomes; Barbosa,Maira Tonidandel; Machado,Thais Helena; Almeida,Mariana Alves deABSTRACT A higher level of educational attainment constitutes a protective factor against cognitive decline in the elderly. Nevertheless, the elements underpinning this association are yet not fully understood. Objective: The primary aim of this study was to compare cognitively impaired illiterate elderly subjects with cognitively preserved counterparts, according to demographics, comorbidities, lifetime habits...
Brazilian cross-cultural translation and adaptation of the "Questionnaire of Li...
Mourao,Aline Mansueto; Araujo,Caroline Martins; Barbosa,Luiz Sergio Mageste; Gomez,Rodrigo Santiago; Burns,Ted M.; Lemos,Stela Maris AguiarObjective To translate and to perform the cross-cultural adaptation of the “Questionnaire of Life Quality Specific for Myasthenia Gravis - 15 items” (MG-QOL15). Method The original English version of the questionnaire was translated into Portuguese. This version was revised and translated back into English. Later, both English versions were compared and the divergences were corrected in the Portuguese text. At ...
Serum levels of soluble TNF-α receptors but not BDNF are associated with apathy...
Guimarães,Henrique Cerqueira; Caramelli,Paulo; Fialho,Patricia Paes Araujo; França,Elisa de Paula; Afonso,Marcelo Pelizzaro Dias; Teixeira,Antonio LucioABSTRACT Apathy is intimately associated with dementia. Unfortunately, its pathophysiology remains poorly understood. The motivational impairment that characterizes this disorder might share the same inflammatory mechanisms, as suggested by the sickness behavior theory. Objective: The primary aim of this study was to investigate the association between apathy symptoms and serum levels of tumor necrosis factor a...
Animal models of neurodegenerative diseases
Ribeiro,Fabiola Mara; Camargos,Elizabeth Ribeiro da Silva; Souza,Leonardo Cruz de; Teixeira,Antonio LucioThe prevalence of neurodegenerative diseases, such as Alzheimer's disease (AD) and Parkinson's disease (PD), increases with age, and the number of affected patients is expected to increase worldwide in the next decades. Accurately understanding the etiopathogenic mechanisms of these diseases is a crucial step for developing disease-modifying drugs able to preclude their emergence or at least slow their progress...
Metisergida como profilaxia de migrânea e cefaleia em salvas, e a possível ocor...
Macedo,Daniela Lino; Soares,Priscila Amorim; Freitas,Denise da Silva; Silva Junior,Ariovaldo Alberto da; Gomez,Rodrigo Santiago; Teixeira,Antonio LucioJUSTIFICATIVA E OBJETIVOS: Metisergida é fármaco de eficácia comprovada na profilaxia tanto da migrânea quanto da cefaleia em salvas, embora possa predispor a fibrose (< 1%). O objetivo deste estudo foi relatar dois casos de cefaleia primária de difícil controle, satisfatoriamente conduzidos com metisergida, que precisou ser interrompida por suspeita de fibrose retroperitoneal (FR). RELATO DOS CASOS: A metiserg...
Cognitive impairment in migraine:A systematic review
Araújo,Caroline Martins de; Barbosa,Izabela Guimarães; Lemos,Stela Maris Aguiar; Domingues,Renan Barros; Teixeira,Antonio LucioABSTRACT Patients with migraine often report cognitive complaints, especially regarding attention and memory. Objective: To perform a systematic review of the studies available on cognitive evaluation in patients with migraine. Methods: We evaluated all articles containing the key words: "Migraine", "Cognition" and "Cognitive Impairment." Results: The search strategy resulted in 23 articles. Fifteen out of the ...