Aberrant Notch signaling is implicated in several cancers, including breast cancer. However, the mechanistic details of the specific receptors and function of ligand-mediated Notch signaling that promote breast cancer remains elusive. In our studies we show that DLL1, a Notch signaling ligand, is significantly overexpressed in ERα+ luminal breast cancer. Intriguingly, DLL1 overexpression correlates with poor pr...
A peeira influencia negativamente diversos aspetos da ovinicultura e tem grande impacto económico e social em diversos países produtores de ovinos de ambos os hemisférios, particularmente na indústria da lã fina,amplamente dominada pelas raças Merinas.Com este trabalho pretendeu-se estimar componentes de variância associados à peeira em ovinos das raças Merina Branca (MB) e Merina Preta (MP), tendo sido realiza...
A peeira influencia negativamente diversos aspetos da ovinicultura e tem grande impacto económico e social em diversos países produtores de ovinos de ambos os hemisférios, particularmente na indústria da lã fina,amplamente dominada pelas raças Merinas.Com este trabalho pretendeu-se estimar componentes de variância associados à peeira em ovinos das raças Merina Branca (MB) e Merina Preta (MP), tendo sido realiza...
The Notch-signaling ligand DLL1 has emerged as an important player and promising therapeutic target in breast cancer (BC). DLL1-induced Notch activation promotes tumor cell proliferation, survival, migration, angiogenesis and BC stem cell maintenance. In BC, DLL1 overexpression is associated with poor prognosis, particularly in estrogen receptor-positive (ER+) subtypes. Directed therapy in early and advanced BC...
Identifying patients with normotensive pulmonary embolism (PE) who may benefit from thrombolysis remains challenging. We sought to develop and validate a score to predict 30-days PE-related mortality and/or rescue thrombolysis. METHODS: We retrospectively assessed 554 patients with normotensive PE. Independent predictors of the studied endpoint were identified from variables available at admission in the emerge...
A infeção por estrongilídeos gastrointestinais tem-se revelado como um dos fatores com maior impacto económico na produção de ovinos. Esse impacto manifesta-se tanto de uma forma direta (tratamento, profilaxia, morte) como de forma indireta (atraso no crescimento, quebras na produção, maior suscetibilidade a outras doenças). O controlo parasitário com base no uso exclusivo de antihelmínticos não se tem revelado...
Background: Tuberculosis (TB) incidence is decreasing worldwide and eradication is becoming plausible. In low-incidence countries, intervention on migrant populations is considered one of the most important strategies for elimination. However, such measures are inappropriate in European areas where TB is largely endemic, such as Porto in Portugal. We aim to understand transmission chains in Porto through a gene...
AIM: Continuous pain occurs routinely, even after invasive procedures, or inflammation and surgery, but clinical practices associated with assessments of continuous pain remain unknown. METHODS: A prospective cohort study in 243 neonatal intensive care units (NICUs) from 18 European countries recorded the frequency of pain assessments, use of mechanical ventilation, sedation, analgesia or neuromuscular blockade...