7 documents found, page 1 of 1
Intraspecific variation of meroditerpenoids in the brown alga Stypopodium zonal...
Soares,Angelica R.; Duarte,Heitor M.; Tinnoco,Luzineide W.; Pereira,Renato C.; Teixeira,Valéria L.Abstract Intraspecific variation on meroditerpenoids production by the brown marine alga Stypopodium zonale at four different populations along the Brazilian coast was analyzed using Principal Component Analysis over high-performance liquid chromatography profiles from algae extracts. The ordination of the samples by the similarities of their chromatographic traits showed the existence of three chemotypes: (i) ...
Inhibitory effect of a Brazilian marine brown alga Spatoglossum schröederi on b...
Domingos,Thaisa Francielle Souza; Ortiz-Ramírez,Fredy A.; Villaça,Roberto C.; Cavalcanti,Diana N.; Sanchez,Eladio F.; Teixeira,Valéria L.The ability of crude extracts of the brown seaweed Spatoglossum schröederi to counteract some of the biological activities of Lachesis muta snake venom was evaluated. In vitro assays showed that only the extract of S. schröederi prepared in ethyl acetate was able to inhibit the clotting of fibrinogen induced by L. muta venom. On the other hand, all extracts were able to inhibit partially the hemolysis caused by...
Marine natural seaweed products as potential antiviral drugs against Bovine vir...
Pinto,Ana Maria Viana; Leite,José Paulo G.; Ferreira,Wilton J.; Cavalcanti,Diana N.; Villaça,Roberto C.; Giongo,Viveca; Teixeira,Valéria L.Bovine viral diarrhea virus (BVDV) is an etiologic agent that causes important economic losses in the world. It is endemic in cattle herds in most parts of the world. The purpose of this study was to evaluate the in vitro cytotoxic effect and antiviral properties of several marine natural products obtained from seaweeds: the indole alkaloid caulerpin (CAV, 1) and three diterpenes: 6-hydroxydichotoma-3,14-diene-...
Allelopathic potential of extracts the from marine macroalga Plocamium brasilie...
Fonseca,Rainiomar Raimundo da; Ortiz-Ramírez,Fredy A.; Cavalcanti,Diana N.; Ramos,Carlos José B.; Teixeira,Valéria L.Four extracts from the marine red alga Plocamium brasiliense (Greville) M.A.Howe & W.R.Taylor were prepared to identify and characterize their potential allelopathic effects on seed germination, radicle elongation and hypocotyl development of the weeds Mimosa pudica L. and Senna obtusifolia (L.) Irwin & Barneby. The four extracts were prepared in a sequence of solvents of increasing polarity: n-hexane, ...
Caulerpin as a potential antiviral drug against herpes simplex virus type 1
Macedo,Nathália Regina Porto Vieira; Ribeiro,Michele S.; Villaça,Roberto C.; Ferreira,Wilton; Pinto,Ana Maria; Teixeira,Valéria L.; Cirne-Santos,ClaudioAbout 80% of the human adult population is infected with HSV-1. Although there are many anti-HSV-1 drugs available (acyclovir, ganciclovir, valaciclovir, foscarnet), their continuous use promotes the selection of resistant strains, mainly in ACV patients. In addition to resistance, the drugs also have toxicity, particularly when administration is prolonged. The study of new molecules isolated from green algae w...
HIV-1 Reverse Transcriptase: a potential target for marine products
Miceli,Leonardo A.; Souza,Alessandra M. T. de; Rodrigues,Carlos R.; Paixão,Izabel C. N. P.; Teixeira,Valéria L.; Castro,Helena C.HIV-1 reverse transcriptase (HIV-1 RT) is a therapeutic target for the treatment of HIV-positive individuals or those already showing AIDS symptoms. In this perspective, the identification of new inhibitors for this enzyme is of great importance in view of the growing viral resistance to the existing treatments. This resistance has compromised the quality of life of those infected with multidrug-resistant strai...
Evaluation of the acute toxicity of dolabelladienotriol, a potential antiviral ...
Garrido,Valéria; Teixeira,Gerlinde A. P. B.; Teixeira,Valéria L.; Ocampo,Patrícia; Ferreira,Wilton J.; Cavalcanti,Diana N.; Campos,Sylvia M. N.Dolabelladienotriol is a product extracted from the brown marine alga Dictyota pfaffii from Brazil that has been shown to have antiviral activity and low cytotoxicity. Our studies have evaluated the acute toxicity of dolabelladienotriol in BALB/c mice for ten days after administration of a single dose. Among the parameters considered were behavior, weight, biochemical and histological analyses of blood samples ...