6 documents found, page 1 of 1
Toxoplasma gondii IgG Serointensity Is Positively Associated With Frailty
Mohyuddin, H; Laffon, B; Teixeira, JP; Costa, S; Teixeira-Gomes, A; Pásaro, E; Constantine, N; Dagdag, A; Ortmeyer, HK; Tizenberg, B; Afram, L; Yen, PYBackground: Persistent inflammation related to aging (inflammaging) is exacerbated by chronic infections and contributes to frailty in older adults. We hypothesized associations between Toxoplasma gondii (T. gondii), a common parasite causing an oligosymptomatic unremitting infection, and frailty, and secondarily between T. gondii and previously reported markers of immune activation in frailty.Methods: We analy...
Comet assay
Costa, S; Pires, J; Teixeira-Gomes, AThe comet assay is a sensitive, inexpensive, fast, and easy-to-use method widely used in genotoxicity testing and biomonitoring studies. It can be applied using a few cells and on almost every cell type to assess a range of different DNA lesions, DNA repair activity and even DNA methylation levels, at the individual cell level. The principle is simple, during electrophoresis relaxed DNA strands move toward the ...
Exploring Early Detection of Frailty Syndrome in Older Adults: Evaluation of Ox...
Teixeira-Gomes, A; Laffon, B; Valdiglesias, V; Gostner, JM; Felder, T; Costa, C; Madureira, J; Fuchs, D; Teixeira, JP; Costa, SAgeing is accompanied with a decline in several physiological systems. Frailty is an age-related syndrome correlated to the loss of homeostasis and increased vulnerability to stressors, which is associated with increase in the risk of disability, comorbidity, hospitalisation, and death in older adults. The aim of this study was to understand the relationship between frailty syndrome, immune activation, and oxid...
Exploring frailty-related biomarkers and potential influence of environmental f...
Teixeira-Gomes, A; Lage, B; Sousa, Ana Catarina; Pastorinho, M. Ramiro; Carvalho, J; Valdiglesias, V; Laffon, B; Teixeira, J.P.; Costa, S.Recent evidence advocates that healthy ageing may be possible, with morbidity compressed to later years. One area of concern is the burden of environmentally induced disease in susceptible populations. Older adults are a well-recognized susceptible population due to the decline of immune defences and the burden of multiple chronic diseases. As a susceptible population, the burden of environmentally induced dise...
Frailty syndrome, biomarkers and environmental factors - A pilot study
Teixeira-Gomes, A; Lage, B; Esteves, F; Sousa, AC; Pastorinho, MR; Valdiglesias, V; Costa, S; Laffon, B; Teixeira, JPFrailty is an age-related syndrome expected to increase over the next decades. This syndrome has been identified to be the most common condition leading to disability, institutionalisation and death in the elderly. The aim of this pilot study is to investigate a possible link between frailty status, biomarkers and environmental exposures. A group of 71 older adults (≥65 years old) was engaged in this study. The...
Occupational exposure to formaldehyde and early biomarkers of cancer risk, immu...
Costa, S; Costa, C; Madureira, J; Valdiglesias, V; Teixeira-Gomes, A; Guedes de Pinho, P; Laffon, B; Teixeira, JPFormaldehyde (FA) is a high-volume production chemical manufactured worldwide to which many people are exposed to both environmentally and occupationally. FA was recently reclassified as a human carcinogen. Several epidemiological studies have revealed an increased risk of cancer development among workers exposed to FA. Although FA genotoxicity was confirmed in a variety of experimental systems, data from human...