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Microleakage Evaluation of Temporary Restorations Used in Endodontic Treatment-...

Paulo, Siri; Abrantes, Ana M.; Xavier, Mariana; Brito, Ana Filipa; Teixo, Ricardo; Coelho, Ana; Paula, Anabela; Carrilho, Eunice

(1) Background: Coronal microleakage can lead to endodontic treatment failure. This study aimed to compare the sealing ability of different temporary restorative materials used during endodontic treatment. (2) Methods: Eighty sheep incisors were collected, uniformized in length, and access cavities were performed, except for in the negative control group, where the teeth were left intact. The teeth were divided...


Localização subcelular do novo fotossensibilizador em células do melanoma ocula...

Guimarães, Tarcísio Guerra; Menezes Cardoso, Karla; Marto, Carlos Miguel; Teixo, Ricardo; Serambeque, Beatriz; Pereira, Nélson; Piñeiro, Marta

Introdução: O melanoma ocular é o objetivo de várias investigações em medicina e medicina veterinária devido à baixa taxa de resposta aos tratamentos conservadores convencionais1. A terapia fotodinâmica (PDT) é uma terapia mais conservadora para os tecidos não neoplásicos, que induz e ativa as vias de morte celular nos tecidos neoplásicos alvo2,3. O fotossensibilizador, luz e oxigenio são os três componentes vi...


Open-Air Cold Plasma Device Leads to Selective Tumor Cell Cytotoxicity

Almeida-Ferreira, Catarina; Silva-Teixeira, Rafael; Laranjo, Mafalda; Almeida, Nuno; Brites, Gonçalo; Dias-Ferreira, João; Marques, Inês A.; Neves, Rita

The need for effective and safe therapies for cancer is growing as aging is modifying its epidemiology. Cold atmospheric plasma (CAP) has gained attention as a potential anti-tumor therapy. CAP is a gas with enough energy to ionize a significant fraction of its constituent particles, forming equal numbers of positive ions and electrons. Timely-resolved output voltage measurement, emission spectroscopy, and quan...


Diabetes mellitus and prostate cancer metabolism: Is there a relationship?

Antunes, Hugo Pontes; Teixo, Ricardo; Carvalho, João André; Eliseu, Miguel; Marques, Inês; Mamede, Ana; Neves, Rita; Oliveira, Rui

Objective: Our aim was to evaluate the effects of glucose levels and diabetes mellitus in prostate cancer (PCa) biology. Materials and methods: Two PCa cell lines (LNCap and PC3) were cultured in RPMI medium with different glucose concentrations [5mM (LG) and 25mM (HG)]. Expressions of androgen receptor, Her2/neu and glucose transporters (GLUT1, 3, 5 and 12) were evaluated by flow cytometry. Proliferation rate ...


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