5 documents found, page 1 of 1
Serum amyloid A proteins reduce bone mass during mycobacterial infections
Gomes, AC; Sousa, DM; Oliveira, TC; Fonseca, O; Pinto, RJ; Silvério, D; Fernandes, AI; Moreira, AC; Silva, T; Teles, MJ; Pereira, L; Saraiva, MIntroductionOsteopenia has been associated to several inflammatory conditions, including mycobacterial infections. How mycobacteria cause bone loss remains elusive, but direct bone infection may not be required. MethodsGenetically engineered mice and morphometric, transcriptomic, and functional analyses were used. Additionally, inflammatory mediators and bone turnover markers were measured in the serum of healt...
Iron Related Biomarkers Predict Disease Severity in a Cohort of Portuguese Adul...
Moreira, AC; Teles, MJ; Silva, T; Bento, CM; Alves, IS; Pereira, L; Guimarães, JT; Porto, G; Oliveira, P; Gomes, MSLarge variability in COVID-19 clinical progression urges the need to find the most relevant biomarkers to predict patients’ outcomes. We evaluated iron metabolism and immune response in 303 patients admitted to the main hospital of the northern region of Portugal with variable clinical pictures, from September to November 2020. One hundred and twenty-seven tested positive for SARS-CoV-2 and 176 tested negative....
Chromosome 6p SNP microhaplotypes and IgG3 levels in hemochromatosis probands w...
Barton, JC; Barton, JC; Cruz, E; Teles, MJ; Guimarães, JT; Porto, GSubnormal IgG1 or IgG3 levels occurred in 30% of hemochromatosis probands with HFE p.C282Y homozygosity and were concordant in HLA-identical siblings. We sought to identify factors associated with IgG subclasses in Alabama probands with p.C282Y homozygosity evaluated for 500 kb microhaplotypes AAT and GGG defined by SNPs in chromosome 6p genes PGBD1, ZNF193, and ZNF165. In regressions on IgG subclasses, we used...
HFE related hemochromatosis: Uncovering the inextricable link between iron home...
Porto, G; Cruz, E; Teles, MJ; Sousa, MThe HFE gene (OMIM 235200), most commonly associated with the genetic iron overload disorder Hemochromatosis, was identified by Feder et al. in 1996, as a major histocompatibilty complex (MHC) class I like gene, first designated human leukocyte antigen-H (HLA-H). This discovery was thus accomplished 20 years after the realization of the first link between the then “idiopathic” hemochromatosis and the human leuk...
Effects of acupuncture on leucopenia, neutropenia, NK, and B cells in cancer pa...
Pais, I; Correia, N; Pimentel, I; Teles, MJ; Neves, E; Vasconcelos, J; Guimarães, J; Azevedo, N; Moreira Pinto, A; Machado, J; Efferth, T; Greten, HJChemotherapy is one of most significant therapeutic approaches to cancer. Immune system functional state is considered a major prognostic and predictive impact on the success of chemotherapy and it has an important role on patients’ psychoemotional state and quality of life. In Chinese medicine, chemotherapy is understood as “toxic cold” that may induce a progressive hypofunctional state of immune system, thus ...