6 documents found, page 1 of 1
Cyclo-(trp-phe) diketopiperazines from the endophytic fungus Aspergillus versic...
Gubiani,Juliana R.; Teles,Helder L.; Silva,Geraldo H.; Young,Maria Cláudia M.; Pereira,José O.; Bolzani,Vanderlan S.; Araujo,Angela R.Six known compounds, three peptide derivatives: cyclo-(tryptophyl-phenylalanyl) (2), diketopiperazine dimer WIN 64821 (3) and 3-hydroxy-15H-tryptophenaline (4), one adenine derivative: 2-hydroxy-6-N-isopentenyl-adenine (5), one phtalide derivative: 4-methoxyphtalide (1) and one benzoic acid derivative: 3-hydroxy-4-(1-hydroxy-1,5-dimethyl-hexyl) benzoic acid (6), were isolated from the ethyl acetate extract of t...
Sesquiterpenos produzidos pelo fungo endofítico Phomopsis cassiae com atividade...
Zanardi,Lisinéia M.; Bolzani,Vanderlan da S.; Cavalheiro,Alberto J.; Silva,Dulce H. Siqueira; Trevisan,Henrique C.; Araujo,Angela R.; Silva,Geraldo H.SESQUITERPENES PRODUCED BY ENDOPHYTIC FUNGUS Phomopsis cassiae WITH ANTIFUNGAL AND ACETYLCHOLINESTERASE INHIBITION ACTIVITIES. Two new diastereoisomeric cadinanes sesquiterpenes 3,9-dihydroxycalamenene (1-2), along with the known 3-hydroxycalamen-8-one (3) and aristelegone-A (4), were isolated from ethyl acetate extract of Phomopsis cassiae, an endophytic fungus in Cassia spectabilis. Their structures, includin...
Development and validation of a HPLC method for standardization of herbal and c...
Batista,Andrea N. de L.; Colombo,Renata; Pascoli,Inara C. de; Teles,Helder L.; Silva,Geraldo H.; Bomfim,Giovanni C. C.; Burgos,Rosilene C. R.Myrcia uniflora Barb. Rodr., Myrtaceae, popularly known as "pedra-hume-caá" in Brazil, is sold as dry extracts in capsules or as tinctures for the treatment of diabetes mellitus. Previous phytochemical studies on this species described the occurrence of the flavonoids mearnsitrin and myricitrin. In the present study, the chromatographic profiles of M. uniflora leaves and commercial extracts were determined usin...
Citocalasinas produzidas por Xylaria sp., um fungo endofítico de Piper aduncum ...
Silva,Geraldo H.; Oliveira,Camila M. de; Teles,Helder L.; Bolzani,Vanderlan da S.; Araujo,Angela R.; Pfenning,Ludwig H.; Young,Maria Claudia M.A chemical study on the EtOAc extract produced by Xylaria sp., an endophytic fungus from Piper aduncum, resulted in the isolation of a new cytochalasin 1, along with five known 19,20-epoxycytochalasin D (2), C (3), N (4), Q (5), and R (6). The 1-6 were evaluated against the fungi C. cladosporioides and C. sphaerospermum and only 5 showed weak activity. The cytotoxicity in vitro against HeLA and CHO cells lines ...
The Styracaceae
Pauletti,Patrícia M.; Teles,Helder L.; Silva,Dulce H.S.; Araújo,Ângela R.; Bolzani,Vanderlan S.The Styracaceae contains 11 genera and approximately 160 species consisting of small trees and shrubs, mostly native to tropical and subtropical regions. This family is well-known by the genus Styrax, which is notorious due to the production of resinous material, a pathological product, harvested by making incisions into the trees bark. The gum is used in perfumes, as antiseptic, expectorant, incense, and fumi...
Substâncias antifúngicas de Xylaria sp., um fungo endofítico isolado de Palicou...
Cafêu,Mariana C.; Silva,Geraldo H.; Teles,Helder L.; Bolzani,Vanderlan da S.; Araújo,Ângela R.; Young,Maria Cláudia M.; Pfenning,Ludwig H.Five compounds, 2-hexyl-3-methyl-butanodioic acid (1), cytochalasin D (2), 7-dechlorogriseofulvin (3), cytochalasin B (4) and griseofulvin (5), have been isolated from the endophytic fungus Xylaria sp., and their structures were elucidated on the basis of spectroscopic data. In the bioautography assay against Cladosporium cladosporioides and Cladosporium sphaerospermum, compounds 1 and 2 were found to be active...