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The hemodynamic response function as a type 2 diabetes biomarker: a data-driven...
Guimarães, Pedro; Serranho, Pedro; Duarte, João V.; Crisóstomo, Joana; Moreno, Carolina; Gomes, Leonor; Bernardes, Rui; Castelo-Branco, MiguelIntroduction: There is a need to better understand the neurophysiological changes associated with early brain dysfunction in Type 2 diabetes mellitus (T2DM) before vascular or structural lesions. Our aim was to use a novel unbiased data-driven approach to detect and characterize hemodynamic response function (HRF) alterations in T2DM patients, focusing on their potential as biomarkers. Methods: We meshed task-b...
Effects of anodal multichannel transcranial direct current stimulation (tDCS) o...
Pereira, H Catarina; Sousa, Daniela; Simões, Marco; Martins, Ricardo Filipe Alves; Amaral, Carlos; Lopes, Vânia; Crisóstomo, JoanaRecent studies suggest that temporoparietal junction (TPJ) modulation can influence attention and social cognition performance. Nevertheless, no studies have used multichannel transcranial direct current stimulation (tDCS) over bilateral TPJ to estimate the effects on these neuropsychological functions. The project STIPED is using optimized multichannel stimulation as an innovative treatment approach for chroni...
ECM-enriched alginate hydrogels for bioartificial pancreas: an ideal niche to i...
Crisóstomo, Joana; Pereira, Ana M.; Bidarra, Sílvia J.; Gonçalves, Ana C.; Granja, Pedro L.; Coelho, Jorge Fj; Barrias, Cristina C; Seiça, RaquelIntroduction: The success of a bioartificial pancreas crucially depends on ameliorating encapsulated beta cells survival and function. By mimicking the cellular in vivo niche, the aim of this study was to develop a novel model for beta cells encapsulation capable of establishing an appropriate microenvironment that supports interactions between cells and extracellular matrix (ECM) components. Methods: ECM compo...
Using Resistin, glucose, age and BMI to predict the presence of breast cancer
Patrício, Miguel; Pereira, José; Crisóstomo, Joana; Matafome, Paulo N.; Gomes, Manuel; Seiça, Raquel; Caramelo, FranciscoBackground: The goal of this exploratory study was to develop and assess a prediction model which can potentially be used as a biomarker of breast cancer, based on anthropometric data and parameters which can be gathered in routine blood analysis. Methods: For each of the 166 participants several clinical features were observed or measured, including age, BMI, Glucose, Insulin, HOMA, Leptin, Adiponectin, Resist...
The Sulforaphane and pyridoxamine supplementation normalize endothelial dysfunc...
Pereira, Ana; Fernandes, Rosa; Crisóstomo, Joana; Seiça, Raquel M.; Sena, Cristina M.In this study we investigate pyridoxamine (PM) and/or sulforaphane (SFN) as therapeutic interventions to determine whether activators of NFE2-related factor 2 (Nrf2) can be used in addition with inhibitors of advanced glycation end products (AGE) formation to attenuate oxidative stress and improve endothelial dysfunction in type 2 diabetes. Goto-kakizaki (GK) rats, an animal model of non-obese type 2 diabetes, ...