4 documents found, page 1 of 1
In vitro trypanocidal evaluation of pinane derivatives from essential oils of r...
Sartorelli,Patricia; Santana,Jefferson S.; Guadagnin,Rafael C.; Lago,João Henrique G.; Pinto,Érika G.; Tempone,André G.; Stefani,Hélio A.Essential oils of ripe fruits from Schinus terebinthifolius (Anacardiaceae), obtained using a pilot extractor and a Clevenger apparatus were chemically characterized. Due the high amount of (-)- α-pinene in both oils, this monoterpene was tested against the protozoan parasite Trypanosoma cruzi, showing a moderate potential (IC50 63.56 µg/mL) when compared to benznidazole (IC50 43.14 µg/mL). Otherwise, (-)- α-pi...
Anti-trypanosomal activity of 1,2,3,4,6-penta-O-galloyl-β -D-glucose isolated f...
Santos,Roberta T. dos; Hiramoto,Liliane L.; Lago,João Henrique G.; Sartorelli,Patrícia; Tempone,André G.; Pinto,Erika G.MeOH extract from the leaves of Plectranthus barbatus Andrews (Lamiaceae), showed in vitro anti-trypanosomal activity. The bioassay-guided fractionation resulted in the isolation of a gallic acid derivative, identified as 1,2,3,4,6-penta-O-galloyl-β-D-glucose (PGG), after thorough NMR and MS spectral analysis. Finally, this compound was tested against trypomastigote forms of T. cruzi and displayed an EC50 value...
Chemical constituents of the volatile oil from leaves of Annona coriacea and in...
Siqueira,Carlos A. T.; Oliani,Jocimar; Sartoratto,Adilson; Queiroga,Carmen L.; Moreno,Paulo R. H.; Reimão,Juliana Q.; Tempone,André G.The essential oil of the leaves from Annona coriacea Mart., Annonaceae, was extracted by hydrodistillation in a Clevenger apparatus and analyzed by GC/MS and GC/FID. The oil yield was 0.05% m/m. Sixty compounds were identified, in a complex mixture of sesquiterpenes (76.7%), monoterpenes (20.0%) and other constituents (3.3%). Bicyclogermacrene was its major compound (39.8%) followed by other sesquiterpenes. Mos...
Isolamento e atividades biológicas de produtos naturais das esponjas monanchora...
Kossuga,Miriam H.; Lira,Simone P. de; Nascimento,Andréa M.; Gambardella,Maria Teresa P.; Berlinck,Roberto G. S.; Torres,Yohandra R.The investigation of extracts from six species of marine invertebrates yielded one new and several known natural products. Isoptilocaulin from the sponge Monanchora aff. arbuscula displayed antimicrobial activity at 1.3 mg/mL against an oxacillin-resistant strain of Staphylococcus aureus. Five inactive known dibromotyrosine derivatives, 2 6, were isolated from a new species of marine sponge, Aplysina sp. The sp...