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Evaluation of real-world mepolizumab use in severe asthma across Europe: the SH...

Kroes, Johannes A; Alfonso-Cristancho, Rafael; Bansal, Aruna T; Berret, Emmanuelle; Bieksiene, Kristina; Bourdin, Arnaud; Brussino, Luisa

Background An objective of the Severe Heterogeneous Asthma Registry, Patient-centered (SHARP) is to produce real-world evidence on a pan-European scale by linking nonstandardised, patient-level registry data. Mepolizumab has shown clinical efficacy in randomised controlled trials and prospective real-world studies and could therefore serve as a proof of principle for this novel approach. The aim of the present ...


What bothers severe asthma patients most? A paired patient-clinician study acro...

Ainsworth, Ben; Chatburn, Eleanor; Bansal, Aruna T.; Fulton, Olivia; Hamerlijnck, Dominique; Coleman, Courtney; Eger, Katrien; Hyland, Michael

Introduction Severe asthma is a complex, multidimensional disease. Optimal treatment, adherence and outcomes require shared decision-making, rooted in mutual understanding between patient and clinician. This study used a novel, patient-centred approach to examine the most bothersome aspects of severe asthma to patients, as seen from both perspectives in asthma registries. Methods Across seven countries, 126 pat...


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