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New polygenic risk score to predict high myopia in Singapore Chinese children

Lança, Carla; Kassam, Irfahan; Patasova, Karina; Foo, Li-Lian; Li, Jonathan; Ang, Marcus; Hoang, Quan V.; Teo, Yik-Ying; Hysi, Pirro G.; Saw, Seang-Mei

Purpose: The purpose of this study was to develop an Asian polygenic risk score (PRS) to predict high myopia (HM) in Chinese children in the Singapore Cohort of Risk factors for Myopia (SCORM) cohort. Methods: We included children followed from 6 to 11 years old until teenage years (12–18 years old). Cycloplegic autorefraction, ultrasound biometry, Illumina HumanHap 550, or 550 Duo Beadarrays, demographics, and...

Date: 2021   |   Origin: Repositório Científico do Instituto Politécnico de Lisboa
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