8 documents found, page 1 of 1
Stress-induced protein disaggregation in the endoplasmic reticulum catalysed by...
Melo, Eduardo; Konno, Tasuku; Farace, Ilaria; Awadelkareem, Mosab Ali; Skov, Lise R.; Teodoro, Fernando; Sancho, Teresa; Paton, Adrienne W.Protein synthesis is supported by cellular machineries that ensure polypeptides fold to their native conformation, whilst eliminating misfolded, aggregation prone species. Protein aggregation underlies pathologies including neurodegeneration. Aggregates' formation is antagonised by molecular chaperones, with cytoplasmic machinery resolving insoluble protein aggregates. However, it is unknown whether an analogou...
Boosting antimicrobial activity of ciprofloxacin by functionalization of mesopo...
Mora, Blanca de Juan; Filipe, Luís; Forte, Andreia; Santos, Miguel M.; Alves, Celso; Teodoro, Fernando; Pedrosa, Rui; Ribeiro Carrott, ManuelaMesoporous silica nanoparticles (MSNs) are very promising nanomaterials for treating bacterial infections when combined with pharmaceutical drugs. Herein, we report the preparation of two nanomaterials based on the immobilization of ciprofloxacin in mesoporous silica nanoparticles,either as the counter-ion of the choline derivative cation MSN-[Ch][Cip]) or via anchoring on the surface of amino-group modified MS...
Mesoporous silica nanoparticles with manganese and lanthanide salts: synthesis,...
Forte, Andreia; Gago, Sandra; Ribeiro Carrott, Manuela; Carrott, Peter; Alves, Celso; Teodoro, Fernando; Pedrosa, Rui; Marrucho, Isabel; Branco, LuísSeveral organic salts based on the combination of two different choline derivative cations and [MnCl3]-, [GdCl4]- and [TbCl4]- as anions, were immobilized in mesoporous silica nanoparticles (MSNs) by a two-step synthetic method. Firstly, MSNs were functionalized with choline derivative cations with chloride anions and then the metals were incorporated by the reaction of the chloride with the respective metal ch...
Mesoporous silica nanoparticles with manganese and lanthanide salts: synthesis,...
Forte, Andreia; Gago, Sandra; Carrott, Manuela Ribeiro; Carrott, Peter; Alves, Celso; Teodoro, Fernando; Pedrosa, Rui; Marrucho, Isabel M.Several organic salts based on the combination of two different choline derivative cations and MnCl3−, GdCl4− and TbCl4− as anions were immobilized in mesoporous silica nanoparticles (MSNs) by a two-step synthetic method. Firstly, MSNs were functionalized with choline derivative cations with chloride anions and then the metals were incorporated by the reaction of the chloride with the respective metal chloride ...
Unravelling the anti-Inflammatory and antioxidant potential of the marine spong...
Gaspar, Helena; Silva, Joana; Alves, Celso; Martins, Alice; Teodoro, Fernando; Susano, Patrícia; Pinteus, Susete; Pedrosa, Rui; Alves, JoanaInflammation is a double-edged sword, as it can have both protective effects and harmful consequences, which, combined with oxidative stress (OS), can lead to the development of deathly chronic inflammatory conditions. Over the years, research has evidenced the potential of marine sponges as a source of effective anti-inflammatory therapeutic agents. Within this framework, the purpose of this study was to evalu...
Boosting antimicrobial activity of ciprofloxacin by functionalization of mesopo...
Juan Mora, Blanca de; Filipe, Luís; Forte, Andreia; Santos, Miguel M.; Alves, Celso; Teodoro, Fernando; Pedrosa, Rui; Carrott, Manuela RibeiroMesoporous silica nanoparticles (MSNs) are very promising nanomaterials for treating bacterial infections when combined with pharmaceutical drugs. Herein, we report the preparation of two nanomaterials based on the immobilization of ciprofloxacin in mesoporous silica nanoparticles, either as the counter-ion of the choline derivative cation (MSN-[Ch][Cip]) or via anchoring on the surface of amino-group modified ...
Highlighting the biological potential of the brown seaweed Fucus spiralis for s...
Freitas, Rafaela; Martins, Alice; Silva, Joana; Alves, Celso; Pinteus, Susete; Alves, Joana; Teodoro, Fernando; Ribeiro, Helena MargaridaSkin aging is a biological process influenced by intrinsic and extrinsic factors. The last ones, mainly exposure to UV radiation, increases reactive oxygen species (ROS) production leading to a loss of extracellular matrix, also enhanced by enzymatic degradation of matrix supporting molecules. Thus, and with the growing demand for eco-friendly skin products, natural compounds extracted from brown seaweeds revea...
Highlighting the Biological Potential of the Brown Seaweed Fucus spiralis for S...
Freitas, Rafaela; Martins, Alice; Silva, Joana; Alves, Celso; Pinteus, Susete; Alves, Joana; Teodoro, Fernando; Ribeiro, Helena MargaridaSkin aging is a biological process influenced by intrinsic and extrinsic factors. The last ones, mainly exposure to UV radiation, increases reactive oxygen species (ROS) production leading to a loss of extracellular matrix, also enhanced by enzymatic degradation of matrix supporting molecules. Thus, and with the growing demand for eco-friendly skin products, natural compounds extracted from brown seaweeds revea...