3 documents found, page 1 of 1
Phenotypic analysis of urothelial exfoliated cells in bladder cancer via microf...
Carvalho, Sandra; Abreu, Catarina M.; Ferreira, Dylan; Lima, Luís; Santos, Lúcio L.; Ribeiro, Ricardo; Grenha, Vânia; Martínez-Fernández, MónicaBladder cancer is the most common malignancy of the urinary tract, having one of the highest recurrence rates and progression from non-muscle to muscle invasive bladder cancer that commonly leads to metastasis. Cystoscopy and urine cytology are the standard procedures for its detection but have limited clinical sensitivity and specificity. Herein, a microfluidic device, the UriChip, was developed for the enrich...
Glycoengineered nanoparticles enhance the delivery of 5-fluoroucil and paclitax...
Fernandes, Elisabete; Ferreira, Dylan; Peixoto, Andreia; Freitas, Rui; Relvas-Santos, Marta; Palmeira, Carlos; Martins, Gabriela; Barros, AnabelaGastric cancer is the third leading cause of cancer-related death worldwide, with half of patients developing metastasis within 5 years after curative treatment. Moreover, many patients cannot tolerate or complete systemic treatment due severe side-effects, reducing their effectiveness. Thus, targeted therapeutics are warranted to improve treatment outcomes and reduce toxicity. Herein, poly(lactic-co-glycolic a...
Glycan affinity magnetic nanoplatforms for urinary glycobiomarkers discovery in...
Azevedo, Rita; Soares, Janine; Gaiteiro, Cristiana; Peixoto, Andreia; Lima, Luís; Ferreira, Dylan; Relvas-Santos, Marta; Fernandes, ElisabeteBladder Cancer (BC) presents one of the highest recurrence rates amongst solid tumours and constitutes the second deadliest disease of the genitourinary track. Non-invasive identification of patients facing disease recurrence and/or progression remains one of the most critical and challenging aspects in disease management. To contribute to this goal, we demonstrate the potential of glycan-affinity glycoproteomi...