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Cytotoxic effects of crotamine are mediated through lysosomal membrane permeabi...

Hayashi, Mirian A.F.; Nascimento, Fábio D.; Kerkis, Alexandre; Oliveira, Vitor; Oliveira, Eduardo B.; Pereira, Alexandre; Rádis-Baptista, Gandhi

Crotamine, one of the main toxic components of Crotalus durissus terrificus venom, is a small non-enzymatic basic polypeptide, which causes hind limb paralysis and necrosis of muscle cells. It is well-known that several toxins penetrate into the cytosol through endocytosis, although in many cases the mechanism by which this occurs has not been fully investigated. Recently, using low concentrations of crotamine,...

Date: 2021   |   Origin: Oasisbr
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